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首页> 外文期刊>Internal medicine. >Late-onset Patients with Sporadic Amyotrophic Lateral Sclerosis in Japan have a Higher Progression Rate of ALSFRS-R at the Time of Diagnosis
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Late-onset Patients with Sporadic Amyotrophic Lateral Sclerosis in Japan have a Higher Progression Rate of ALSFRS-R at the Time of Diagnosis

机译：在日本，散发性肌萎缩性侧索硬化症的迟发患者在诊断时ALSFRS-R的进展率较高

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Objective The population in Japan is aging at a faster rate than in other countries in the world. It is speculated that the number of patients with late-onset amyotrophic lateral sclerosis (ALS) will increase even more in the future. However, few studies have been undertaken on the characteristics of patients with late-onset ALS in Japan. This study sought to investigate the clinical features of patients with late-onset ALS compared with those with early-onset ALS using the progression rate (ΔFS). Methods Forty-five patients with sporadic ALS were divided into 2 groups: 23 patients with early-onset of ALS (<65 years; early onset) and 22 patients with late-onset ALS (≥65 years; late onset). Every patient was followed up from the time of initial diagnosis to the primary endpoint (death or time culminating in death without tracheostomy or ventilation assistance including noninvasive positive pressure ventilation) or for at least 48 months after initial diagnosis. Results ΔFS in the patient group with late onset was significantly higher than that of the group with early onset (p=0.010). Survival of patients with late onset was significantly decreased compared to that of patients with early onset (p=0.031). Conclusion Our finding suggested that patients with late-onset ALS showed more rapid disease progression than those with early-onset ALS using ΔFS.
机译：目标日本的人口老龄化速度快于世界其他国家。据推测，迟发性肌萎缩性侧索硬化症（ALS）的患者人数将来会增加。但是，在日本，关于晚期ALS患者的特征的研究很少。本研究试图使用进展率（ΔFS）来研究晚期ALS患者与早期ALS患者的临床特征。方法将45例散发性ALS患者分为两组：23例ALS早发（<65岁;早发）和22例ALS早发（≥65岁;晚发）。从初次诊断到主要终点（没有气管切开术或不包括无创正压通气在内的通气辅助在内的死亡或死亡最终死亡时间）或初诊后至少48个月进行随访。结果迟发患者组的ΔFS明显高于早发患者组（p = 0.010）。与早期发作的患者相比，晚期发作的患者的存活率显着降低（p = 0.031）。结论我们的发现表明，使用ΔFS的晚期ALS患者比早期ALS患者疾病进展更快。

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