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首页> 外文期刊>International Journal of Advanced Biotechnology and Research >Association study of rs1994016 polymorphism on ADAMTS-7 loci with Coronary Artery Disease in the Iranian population
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Association study of rs1994016 polymorphism on ADAMTS-7 loci with Coronary Artery Disease in the Iranian population

机译：伊朗人群ADAMTS-7基因座rs1994016多态性与冠状动脉疾病的关联研究

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Coronary artery disease (CAD) is the single greatest cause of death worldwide. Although CAD is highly heritable, theDNA sequence variations that confer cardiovascular risk remain largely unknown. Definition of the geneticarchitecture of CAD can provide substantial benefits through improved risk prediction and development of noveltherapies. Genome-wide association studies of coronary artery disease have recently identified a new susceptibilitylocus, ADAMTS-7, in subjects of European ancestry. However, the significance of this locus in Iranian populationshas not been identified. This study was designed to evaluate the effect of rs1994016, a non-synonymous variant in theprodomain of the ADAMTS-7 protease, on CAD risk and atherosclerosis severity in an Iranian population. Geneticperformed association analyses through TaqMan probe real time PCR technique in a case-control cohort, whichincluded a total of 200 participants. Based on angiography test results and biochemical characteristics, participantswere divided into two case and control groups (more than 50% stenosis in coronary arteries was considered as case(n=100), and less than 50% stenosis in coronary arteries was considered as control (n=100). Blood samples werecollected and DNA was extracted for evaluation of rs1994016. Final results and clinical and biomedical characteristicswere analyzed statistically. According to the data, ADAMTS-7 rs1994016 was significantly associated withsusceptibility to CAD in the studied population of patients with CAD [odds ratio (OR) = 0.013, 95 % confidenceinterval (CI) = 0.003-0.059, P < 0.001]. The frequency of the T mutant allele was considerably higher in the casegroup. (T allele Frequency in cases: 0.81 and in controls: 0.1). These results suggested ADAMTS-7 rs1994016 wereassociated with susceptibility to CAD in Iranian population.
机译：冠状动脉疾病（CAD）是全球范围内最大的死亡原因。尽管CAD具有很高的遗传性，但导致心血管疾病风险的DNA序列变异仍然未知。 CAD的遗传体系结构的定义可以通过改进的风险预测和新型疗法的开发来提供实质性的收益。冠状动脉疾病的全基因组关联研究最近在欧洲血统的受试者中发现了一种新的易感基因座ADAMTS-7。但是，尚未确定该基因座在伊朗人口中的重要性。本研究旨在评估rs1994016（ADAMTS-7蛋白酶前域中的一个非同义词变体）对伊朗人群中CAD风险和动脉粥样硬化严重程度的影响。通过病例对照队列中的TaqMan探针实时PCR技术对遗传进行的关联分析，共有200名参与者。根据血管造影检查结果和生化特征，将参与者分为病例组和对照组（将大于50％的冠状动脉狭窄视为病例（n = 100），将小于50％的冠状动脉狭窄视为对照组（ （n = 100）。采集血样并提取DNA进行rs1994016的评估，对最终结果以及临床和生物医学特征进行统计学分析，根据数据，ADAMTS-7 rs1994016与研究过的CAD患者易感性显着相关。 [几率（OR）= 0.013，95％置信区间（CI）= 0.003-0.059，P <0.001]。病例组中T突变等位基因的频率明显更高（病例中T等位基因频率：0.81和对照组） ：0.1）。这些结果表明ADAMTS-7 rs1994016与伊朗人群中CAD的易感性有关。

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