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首页> 外文期刊>International Journal of Advanced Biotechnology and Research >Comparison the Effect of Aqua-Alcoholic Root Extract of Glycyrrhiza Glabra and Chlorhexidine on Candida Albicans (Invitro)
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Comparison the Effect of Aqua-Alcoholic Root Extract of Glycyrrhiza Glabra and Chlorhexidine on Candida Albicans (Invitro)

机译：甘草和洗必泰水酒精根提取物对白色念珠菌的作用比较

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Introduction: Candida Albicans as the most common opportunistic microorganism is responsible for sever oral cavityinfection in human beings. To control this infection, usually mouthwashes and medications such as Chlorhexidine andNystatin have been used. Recently with regard to the side effects of chemical mouthwashes, herbal products in form ofmouth rinses have been increasingly used and studied. Glycyrrhiza Glabra is an effective herbal mouth rinse todecrease and control tooth caries. The aim of this study was to compare the antifungal effect of aqua-alcoholic rootextract of Glycyrrhiza Glabra(G.G) and Chlorhexidine on Candida Albicans (C.A).Materials and methods: In this experimental study antifungal effect of glycyrrhiza glabra aqua-alcoholic root extractwas evaluated using disk diffusion test (DIT) by measuring growth inhibition hallow diameter in both case and controlgroups. Minimal Inhibitory Concentration (MIC) was assessed by Broth Dilution Test (BDT) and then MinimumFungicidal Concentration (MFC) was evaluated by Agar Dilution Method (ADM) in specific fungal culturemedia.Each test was performed three times in both groups and results were statistically analyzed by ANOVA testprimarily and complementary Scheffe test if needed (p<0.01).Findings: Chlorhexidine, showed significant antifungal effects on C.A but Glycyrrhiza Glabra root extract had nosignificant effect on C.A. The antifungal effects of chlorhexidine 0.2% as compared to chlorhexidine 0.12% and alsoto aqua-alcoholic extract of Glycyrrhiza Glabra was significantly higher (p <0.01).Conclusion: It seems that aqua-alcoholic root extract of Glycyrrhiza Glabra has no significant antifungal effect oncandida albicans, and in comparison with chlorhexidine is obviously less effective.
机译：简介：白色念珠菌是最常见的机会微生物，可导致人类严重口腔感染。为了控制这种感染，通常使用漱口水和诸如洗必泰和制霉菌素的药物。最近，关于化学漱口水的副作用，以漱口水形式的草药产品已得到越来越多的使用和研究。甘草是一种有效的草药漱口水，可减少和控制龋齿。这项研究的目的是比较甘草的含水酒精根提取物（GG）和洗必泰对白色念珠菌（CA）的抗真菌作用。材料和方法：本实验研究评估了甘草的含水酒精根提取物的抗真菌作用。使用圆盘扩散测试（DIT）通过测量病例组和对照组的生长抑制圣殿直径。通过肉汤稀释试验（BDT）评估最小抑菌浓度（MIC），然后通过琼脂稀释法（ADM）评估特定真菌培养基中的最小杀菌浓度（MFC），两组分别进行3次试验，并对结果进行统计学分析主要通过ANOVA试验和必要时通过补充Scheffe试验进行分析（p <0.01）。发现：洗必太对CA具有明显的抗真菌作用，而甘草根提取物对CA则无显着影响氯己定0.2％比氯己定0.12％对甘草的水醇提取物的抗真菌作用明显更高（p <0.01）。结论：看来甘草的水醇根提取物对假丝酵母没有明显的抗真菌作用。与白色洗必泰相比，效果明显较差。

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