Amino Coated Gold Nanorods Based Amperometric Glucose Detection

Shikha Sharma; Navendu Goswami; Nidhi Gupta; Sudha Srivastava

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Amino Coated Gold Nanorods Based Amperometric Glucose Detection

机译：基于氨基涂层的金纳米棒的安培葡萄糖检测

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Citrate capped gold nanoseeds of uniform size and shape were prepared and used for CTAB-assisted growth of gold nanorods. Further, shape and size dependent hydrodynamic sedimentation behavior of nanostructure is exploited for separation of gold nanorods from mixture containing particles of different shape and size. The surface functionalization of gold nanorods with amino acids allows its efficient interaction with the enzyme and makes it a promising platform for applications including medical diagnostics and sensing devices. Further, the biosensing efficiency of the glucose biosensor fabricated by immobilizing glucose oxidase (GOx) onto gold nanorods was investigated. Under optimum conditions, the fabricated biosensor showed low detection limit, excellent storage stability and high sensitivity. The biosensor has a wide linear range for the detection of glucose from 5mM to 40mM with 6 s response time. The retained activity of glucose oxidase ensures the biocompatibility of amino coated gold nanorods and shows that it can be extended to other enzymes as well for development of novel biosensors.

机译：制备大小和形状均一的柠檬酸盐包覆的金纳米种子，并用于CTAB辅助金纳米棒的生长。此外，利用形状和尺寸依赖性的纳米结构的流体动力学沉积行为来从包含不同形状和尺寸的颗粒的混合物中分离金纳米棒。金纳米棒与氨基酸的表面功能化使其能够与酶高效相互作用，使其成为包括医学诊断和传感设备在内的应用的有前途的平台。此外，研究了通过将葡萄糖氧化酶（GOx）固定在金纳米棒上而制造的葡萄糖生物传感器的生物传感效率。在最佳条件下，所制造的生物传感器显示出低检测限，优异的储存稳定性和高灵敏度。该生物传感器具有很宽的线性范围，可在6 s的响应时间内检测5mM至40mM的葡萄糖。葡萄糖氧化酶的保留活性确保了氨基包覆的金纳米棒的生物相容性，并表明它可以扩展到其他酶，以开发新型生物传感器。

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《International Journal of Advancements in Technology》 |2012年第3期|共8页
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Shikha Sharma; Navendu Goswami; Nidhi Gupta; Sudha Srivastava;
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1. In vivo 'real-time' monitoring of glucose in the brain with an amperometric enzyme-based biosensor based on gold coated tungsten (W-Au) microelectrodes [J] . C.A. Cordeiro, A. Sias, T. Koster, Sensors and Actuators . 2018,第JUNa期

机译：使用基于电流的酶基生物传感器基于镀金钨（W-Au）微电极的体内“实时”监测大脑中的葡萄糖
2. Amperometric glucose biosensor based on gold nanorods and chitosan comodified Au electrode [J] . LI Yingying, WANG Xiaoxia, DONG Xiang, 稀有金属：英文版 . 2010,第003期

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3. Layer-by-Layer Self-Assembling Gold Nanorods and Glucose Oxidase onto Carbon Nanotubes Functionalized Sol-Gel Matrix for an Amperometric Glucose Biosensor [J] . Baoyan Wu, Cong Zhang, Ming Su, Nanomaterials . 2015,第3期

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4. Pt based Nanocomposites for Direct Glucose Determination Sensitive Nonenzymatic Amperometric Glucose Detection by Carbon Supported PtAu based bimetallicNanomaterials [C] . Baljit Singh, Eithne Dempsey Fullerenes, nanotubes, and carbon nanostructures - 219th ECS meeting. . 2011

机译：碳载PtAu基双金属纳米材料直接用于葡萄糖测定的基于Pt的纳米复合材料灵敏的非酶安培葡萄糖检测
5. Fabrication and Environmental Applications of Silver Coated Gold Nanorods/ Electrospun Polymer Fiber Matrix for Use as Surface Enhanced Raman Scattering Substrates [D] . Xu, Shuyu. 2018

机译：涂银金纳米棒/电纺聚合物纤维基体用作表面增强拉曼散射基底的制备及环境应用
6. Layer-by-Layer Self-Assembling Gold Nanorods and Glucose Oxidase onto Carbon Nanotubes Functionalized Sol-Gel Matrix for an Amperometric Glucose Biosensor [O] . Baoyan Wu, Shihua Hou, Zhiying Miao, 2015

机译：碳纳米管上的层自组装金纳米棒和葡萄糖氧化酶的功能化的安培葡萄糖生物传感器的溶胶凝胶基质。
7. Layer-by-Layer Self-Assembling Gold Nanorods and Glucose Oxidase onto Carbon Nanotubes Functionalized Sol-Gel Matrix for an Amperometric Glucose Biosensor [O] . Baoyan Wu, Shihua Hou, Zhiying Miao, 2015

机译：逐层自组装金纳米棒和葡萄糖氧化酶到碳纳米管功能化溶胶 - 凝胶基质上的电流型葡萄糖生物传感器

Amino Coated Gold Nanorods Based Amperometric Glucose Detection

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