Influence of RKIP Protein Complexes Concentrations on the Quasi-Stationary Behaviour of the MEK/ERK Signal Transduction Pathway

Nikolova E.; Petrov V.

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Influence of RKIP Protein Complexes Concentrations on the Quasi-Stationary Behaviour of the MEK/ERK Signal Transduction Pathway

机译：RKIP蛋白复合物浓度对MEK / ERK信号转导途径拟平稳行为的影响

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It is considered the quasi-stationary approximation of a dynamic model, representing a positive feedback mechanism in the MEK/ERK signaling pathway mediated by RKIP. An analytical solution of the eight dimensional quasi-stationary system is found. Analytical relations between stationary and initial values of all signal pathway components are derived too. On the basis of them it is established that the quasi-stationary behaviour of a MEK/ERK pathway is dependent only on reactions of association and dissociation of the double phosphorylated protein ERKpp and the protein complex RKIP/Raf-1 to the three-component complex ERKpp/RKIP/Raf-1 and vice versa. Moreover, the leading role of initial concentrations of the RKIP protein complexes is determined

机译：它被认为是动态模型的准平稳逼近，它表示由RKIP介导的MEK / ERK信号通路中的正反馈机制。找到了八维准平稳系统的解析解。还得出所有信号通路成分的固定值和初始值之间的分析关系。基于它们，建立了MEK / ERK途径的准平稳行为仅取决于双磷酸化蛋白ERKpp和蛋白复合物RKIP / Raf-1至三组分复合物的缔合和解离反应。 ERKpp / RKIP / Raf-1，反之亦然。此外，确定了RKIP蛋白复合物初始浓度的主导作用

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《International Journal Bioautomation》 |2007年第2期|共8页
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Nikolova E.; Petrov V.;
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中图分类生物工程学（生物技术）;
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7. Influence of RKIP Protein Complexes Concentrations on the Quasi-Stationary Behaviour of the MEK/ERK Signal Transduction Pathway [O] . Petrov V., Nikolova E. 2007

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Influence of RKIP Protein Complexes Concentrations on the Quasi-Stationary Behaviour of the MEK/ERK Signal Transduction Pathway

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