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首页> 外文期刊>International Journal of Applied and Basic Medical Research >Evaluation of calabash chalk effect on femur bone morphometry and mineralization in young wistar rats: A pilot study
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Evaluation of calabash chalk effect on femur bone morphometry and mineralization in young wistar rats: A pilot study

机译：葫芦粉对幼龄Wistar大鼠股骨骨形态和矿化的影响的初步研究

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Background:Calabash chalk, a popularly consumed geophagic material in Nigeria has been reported to contain lead, arsenic, alpha lindane, endrin, and endosulfan 11 among other pollutants.Aim:The continuous exposure of young children to this chalk necessitated this study on the bone morphometry and mineralization in young Wistar rats.Materials and Methods:Fourteen young (weanling) Wistar rats of both sexes weighing 54-72 g were assigned into two groups of seven animals each. Group I served as control, while group II was the test group (TG). 40 mg/ml of C. chalk was administered as suspension to the test animals in group II. Animals in the control group were orally treated with 1ml of distilled water. Administration of the C. chalk in the animals lasted for 28 days, and the animals were sacrificed on day 29, using chloroform anaesthesia. The femur bones were dissected out, cleaned of flesh and sun-dried. The lengths and weights of the femur bones were measured using graphite furnace atomic mass spectrophotometer.Results:Results showed 1.6% decrease in body weight change in the TG, insignificant decreases in the weights and lengths of both the right and left femur bones, and significant decreased (P < 0.0126) organ-somatic index, and femur bones concentrations (mg/l) of zinc, phosphate, carbonate, calcium, sodium, and potassium (P < 0.05).Conclusion:In conclusion, this study showed that C. chalk may alter growth rate, and cause de-mineralization in the femur bone, hence, it may be detrimental to bone growth.
机译：背景：据报道，尼日利亚粉笔中消耗最广的地相物质-粉笔-含有铅，砷，α-林丹，异狄氏剂和硫丹11等其他污染物。目的：幼儿不断接触该粉笔需要对骨骼进行此项研究材料和方法：将十四只体重为54-72 g的幼（断奶）Wistar大鼠分为两组，每组七只动物。第一组作为对照组，第二组作为测试组（TG）。将40mg / ml白垩病粉笔作为悬浮液给予第二组中的试验动物。对照组动物用1ml蒸馏水口服处理。在动物中对白垩病的施用持续28天，并在第29天使用氯仿麻醉处死动物。解剖出股骨，清除肉并晒干。结果：结果表明，TG的体重变化减少了1.6％，左右股骨的重量和长度均无明显减少，并且显着降低了股骨的长度和重量。结论：这项研究表明，C。白垩可能会改变生长速度，并导致股骨骨骼脱矿质，因此可能对骨骼生长有害。

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