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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Effect of vitamin A supplementation in category-I Pulmonary Tuberculosis patients in a Medical College in India: a rapid assessment analysis
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Effect of vitamin A supplementation in category-I Pulmonary Tuberculosis patients in a Medical College in India: a rapid assessment analysis

机译：补充维生素A在印度医学院的I类肺结核患者中的作用：快速评估分析

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Background: Tuberculosis is one of the major health problems affecting the global population causing immense morbidity and mortality. Studies have shown that a good antioxidant status of the body has immune protective role against tuberculosis and may be associated with a decreased risk of the disease and slower rate of progression. Objective of the study was planned to evaluate the beneficial effects of Vitamin A as add on therapy to the standard drug therapy in patients with sputum positive pulmonary tuberculosis. Methods: The study was done in a Tuberculosis clinic, Department of Internal Medicine, Stanley Medical College for duration of 6 months. All the newly diagnosed sputum positive pulmonary tuberculosis patients (18-55 years) attending the outpatient were taken for the study purpose. A Phase III, prospective, open, two arm parallel group, outpatient, randomized, active controlled study was done. Results: After two weeks of therapy, the number of patients with negative sputum smear was higher in the study group than the control group. Vitamin A supplementation resulted in an earlier elimination of tubercle bacilli from the sputum. Conclusions: This study shows that vitamin A as add on therapy to the existing standard therapy improves the clinical response and decreases the disease activity to a greater extent than with routine standard therapy alone.
机译：背景：结核病是影响全球人口的主要健康问题之一，导致巨大的发病率和死亡率。研究表明，身体良好的抗氧化状态具有抵抗结核病的免疫保护作用，并且可能与疾病风险降低和疾病进展速度降低有关。计划研究的目的是评估维生素A补充对痰阳性肺结核患者的标准药物治疗的疗效。方法：该研究在斯坦利医学院内科系结核病诊所进行，为期6个月。所有参加门诊的新确诊的痰阳性肺结核患者（18-55岁）均作为研究目的。进行了III期，前瞻性，开放，两臂平行组，门诊，随机，主动对照研究。结果：治疗两周后，研究组痰涂片阴性患者的数量高于对照组。补充维生素A可以更早地消除痰中的结核杆菌。结论：这项研究表明，与仅使用常规标准疗法相比，将维生素A作为现有标准疗法的补充疗法可改善临床反应并降低疾病活动。

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