Background: Alleviation of pain has always remained a prime concern of medicine. Numbers of anti-inflammatory and analgesic drugs like aspirin, indomethacin, phenylbutazone etc. are in practice, but because of their side effects, there is extensive search for new drugs and molecules with fewer side effects. Search for newer anti-inflammatory and analgesic agents having better or at least equal efficacy with minimal side effects is continuing throughout the world. Therefore, the search should continue and it is felt that herbal medicine has still a lot in store. Aegle marmelos is one of the most frequently used plant in the traditional and folklore systems of medicine and in religious rituals. Various activities of different parts like roots, leaves, flowers, fruits and seeds of AM were evaluated. It has analgesic, anti-inflammatory, antipyretic, antidiabetic, antioxidant, hepatoprotective and many other activities. Methods: Analgesic activities of AMSBAE (50,100 and 200 mg/kg p.o.) were studied using tail flick test and acetic acid-induced writhes in rats and mice respectively. Results: AMSBAE produces dose dependent analgesic activity in the tail flick test and acetic acid-induced writhing in mice (P Conclusions: AMSBAE has analgesic activity. The analgesic activity of AMSBAE was comparable to that of tramadol and Aspirin. Hence, AMSBAE could be a possible alternative to NSAIDs.
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机译：背景：减轻疼痛一直是医学的主要问题。实际上，有许多消炎和镇痛药，例如阿司匹林，消炎痛，苯基丁a等，但由于它们的副作用，人们正在广泛寻找副作用较少的新药和分子。在世界范围内，一直在寻找具有更好或至少相等疗效且副作用最小的新型抗炎和镇痛药。因此，应该继续进行搜索，并且认为草药还有很多存储空间。在传统的和民间传说的医学系统以及宗教仪式中，马格洛斯山羊是最常用的植物之一。评价了AM的根，叶，花，果实和种子等不同部位的各种活性。它具有止痛，消炎，解热，抗糖尿病，抗氧化剂，保肝和许多其他活性。方法：采用甩尾试验和乙酸诱导的大鼠和小鼠的扭伤研究AMSBAE（50,100和200 mg / kg p.o.）的镇痛活性。结果：AMSBAE在甩尾试验中产生剂量依赖性的镇痛活性，并在小鼠乙酸中引起扭体（P结论：AMSBAE具有镇痛活性。AMSBAE的镇痛活性可与曲马多和阿司匹林相媲美。 NSAID的可能替代品。
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