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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >A study on incidence of adverse drug reactions with commonly prescribed drugs and causality assessment in Silchar Medical College and Hospital
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A study on incidence of adverse drug reactions with commonly prescribed drugs and causality assessment in Silchar Medical College and Hospital

机译：西尔沙尔医学院和医院的常用药物不良药物反应发生率和因果关系评估的研究

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Background: Present study was carried out to assess the incidence of adverse drug reactions (ADRs) and assessment of causality, severity with reported suspected ADRs. Methods: A prospective observational study was conducted over a period of one year in inpatients and out patients hospitalization due to ADRs, at Silchar Medical College & Hospital, Silchar, Assam. WHO–UMC Probability scale was used for causality assessment. Reported ADRs were classified according to Wills and Brown classification and assessed for severity using scale developed by Hartwig et al. All data were calculated by ‘Descriptive statistics’ analysis as percentage of patient population who encountered ADRs. Results: A total of 192 suspected ADRs were reported and Overall incidence of ADRs during the study period was found to be 0.41% of which 0.22% of ADRs had lead to hospital admissions and 0.19% of ADRs occurred during the hospital stay. Most common drug class associated with ADRs were Antimicrobials [101(52.6%)], which was found to have mostly affected the Skin system followed by NSAIDs [24(13.54%)], Haematinics [21(10.93%)]. Severity of the ADRs were found to be moderate [79(41.14%)], followed by [71 (36.97%)] ADRs which were severe and [42(21.87%)] which were mild. Conclusions: Present study revealed that, more awareness about the importance of Pharmacovigilance have to be provided among the health care professionals by way of ADR bulletins, seminars and workshops. Also, more studies need to be conducted in Indian population to know the exact prevalence of ADRs in Indian hospitals.
机译：背景：本研究旨在评估药物不良反应（ADR）的发生率，并评估所报告的可疑ADR的因果关系，严重性。方法：在阿萨姆邦西尔沙尔的西尔沙尔医学院和医院，对因ADR住院和住院的患者进行了为期一年的前瞻性观察研究。 WHO-UMC概率量表用于因果关系评估。根据Wills和Brown分类对报告的ADR进行分类，并使用Hartwig等人开发的量表评估其严重性。所有数据均通过“描述性统计”分析计算为遇到ADR的患者人数百分比。结果：总共报告了192个可疑ADR，研究期间ADR的总发生率为0.41％，其中0.22％的ADR导致住院，而0.19％的ADR发生在住院期间。与ADR相关的最常见药物类别是抗菌药[101（52.6％）]，被发现对皮肤系统的影响最大，其次是NSAIDs [24（13.54％）]，Haematinics [21（10.93％）]。发现ADR的严重程度为中度[79（41.14％）]，其次是[71（36.97％）]为严重的ADR，[42（21.87％）]为轻度。结论：本研究表明，必须通过ADR公告，研讨会和讲习班，在医疗保健专业人员中提高对药物警戒重要性的认识。另外，需要对印度人群进行更多的研究，以了解印度医院中ADR的确切患病率。

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