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首页> 外文期刊>International Journal of Basic and Applied Sciences >Application of Bethesda terminology to categorize buccal epithelial smears among petroleum station workers in Taif city, KSA
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Application of Bethesda terminology to categorize buccal epithelial smears among petroleum station workers in Taif city, KSA

机译：贝塞斯达（Bethesda）术语在KSA台夫市加油站工作人员的颊上皮涂片分类中的应用

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Background and Objectives: Exposure to Petroleum products has a well-established mutagenicity and carcinogenicity of some compo-nents such as benzene. Buccal mucosal cells are capable of metabolizing the carcinogenic compounds to reactive chemicals. We investigated the buccal epithelial cell cytological changes resulting from the occupational exposure to Petroleum derivatives such as benzene. Methods: Samples were obtained from 70 Petrol station workers in Taif city-KSA, examined using the Papanicolaou stained smears and categorized based on Bethesda Terminology System. Statistical analysis was carried out with the SPSS. Results: About 38.6% of petrol station workers exhibited buccal cytological changes ranging from atypical squamous cells of undetermined significance (ASC-US) to high-grade squamous intraepithelial lesions (HSIL). Atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) was the most frequent cytological abnormality. Buccal smears with abnormal cytological findings dominated among smokers in contrast to non-smokers with a statistically significant difference (P = 0.026). No significant associations were detected between the category of buccal cytological changes and the duration of work or the participant's age. Conclusion: Bethesda Terminology System can be efficiently applied to buccal smears. Petrol products induce precancerous epithelial changes in buccal epithelial cells indicating a potential health risk for Petrol station workers, thus annual checkup for those workers should be set as primary prevention of occupational-related cancer. Cigarette smoke is a co-factor that exacerbates the effects of Petrol derivatives.
机译：背景与目的：接触石油产品对某些成分（如苯）具有公认的致突变性和致癌性。颊粘膜细胞能够将致癌化合物代谢为反应性化学物质。我们调查了职业性接触石油衍生物（例如苯）导致的颊上皮细胞的细胞学变化。方法：从塔伊夫市KSA的70个加油站工作人员获取样本，使用Papanicolaou染色涂片进行检查，并根据Bethesda术语系统进行分类。用SPSS进行统计分析。结果：约38.6％的加油站工人表现出颊部细胞学变化，范围从意义不明的非典型鳞状细胞（ASC-US）到高度鳞状上皮内病变（HSIL）。非典型鳞状细胞不能排除高度鳞状上皮内病变（ASC-H）是最常见的细胞学异常。与非吸烟者相比，在吸烟者中以细胞学检查结果异常为特征的颊涂片占主导地位（P = 0.026）。在颊细胞学改变的类别与工作时间或参与者的年龄之间没有发现显着的关联。结论：贝塞斯达术语系统可以有效地应用于颊涂片检查。汽油产品会诱发颊上皮细胞癌前上皮的变化，表明加油站工作人员可能面临健康风险，因此应每年对这些工作人员进行检查，将其作为职业性癌症的主要预防措施。香烟烟雾是加剧汽油衍生物影响的辅助因素。

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