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首页> 外文期刊>Journal of Environmental and Public Health >Impact of Petroleum Exposure on Some Hematological Indices, Interleukin-6, and Inflammatory Markers of Workers at Petroleum Stations in Basra City
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Impact of Petroleum Exposure on Some Hematological Indices, Interleukin-6, and Inflammatory Markers of Workers at Petroleum Stations in Basra City

机译：巴士拉市石油站血液依照，白细胞介素-6和工人炎症标志物的影响

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Background. Occupational and environmental exposure to several pollutant factors such as petroleum products containing benzene has toxic effects on different body systems. The hematopoietic system and immune system are among the affected systems. This study aims to investigate the effect of benzene exposure on some blood parameters of workers at several fuel stations in Basra city, as well as to reveal if the continuous exposure may induce an inflammatory response, which is reflected by changes in some hematological and inflammatory markers. Methods. The study included two groups of males. The first group consists of 72 exposed workers at petrol stations in different locations in the Basra city. The other group is the control group, which consists of 75 nonexposed subjects (students and faculty members of the college). Different hematological parameters (WBC, RBC, HGB, MCV, MCHC, and MCH) have been evaluated. Serum concentrations of IL-6 and hs-CRP were estimated in all workers and nonexposed using enzyme-linked immunosorbent assay (ELISA). Results. Data showed significant hematological changes in the exposed workers, and that anemia was a common disorder among them. Furthermore, there was a significant decline in WBC and different types of WBC including lymphocytes, monocytes, and neutrophils in the exposed workers. Erythrocyte sedimentation rate and serum levels of interleukin-6 and hs-CRP were significantly higher in exposed workers than in nonexposed. A significant correlation was identified among blood parameters, while a strong inverse correlation was identified between both MCHC and ESR. The most significant inverse correlation was found between RBC and IL-6 and MCH with hs-CRP. In addition, a significant negative correlation was found between monocytes and IL-6. Conclusion. The changes in all hematology and inflammatory parameters refer to damage in the hematopoietic system due to continuous exposure to vapors of petrol products, which also result in a significant increase in interleukin-6.
机译：背景。职业和环境暴露于几种污染物因子，例如含有苯的石油产品对不同体系具有毒性作用。造血系统和免疫系统是受影响的系统之一。本研究旨在探讨苯暴露对巴士拉城几种燃料站的一些血液参数的影响，以及持续暴露可能诱导炎症反应，这被一些血液学和炎症标志物的变化反映。方法。该研究包括两组雄性。第一个集团由巴士拉市不同地点的汽油站的72名暴露工人组成。另一组是对照组，其中由75个非爆炸科目（学院和学院的学生和教师）组成。已经评估了不同的血液学参数（WBC，RBC，HGB，MCV，MCHC和MCH）。在所有工人估计IL-6和HS-CRP的血清浓度，并非使用酶联免疫吸附测定（ELISA）中的任何一个。结果。数据显示出暴露工人的显着血液学变化，贫血是其中的常见疾病。此外，WBC和不同类型的WBC患有淋巴细胞，单核细胞和中性粒细胞在暴露工人中的显着下降。暴露工人的红细胞沉积率和白细胞介素-6和HS-CRP的血清水平明显高于中未缺陷。血液参数之间鉴定了显着的相关性，而MCHC和ESR之间识别出强的反相。 RBC和IL-6和MCH与HS-CRP之间的最显着的反相。此外，单核细胞和IL-6之间发现了显着的负相关。结论。由于连续暴露于汽油产品蒸气，所有血液学和炎症参数的变化是指造血系统中的损伤，这也导致白细胞介素-6的显着增加。

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