Aza-and carba-Michael Adducts as Building Blocks in Heterocyclic Synthesis

Maher.A.EL-Hashash; Sameh. A. Rizk; and Yaser A.El-Badry

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Aza-and carba-Michael Adducts as Building Blocks in Heterocyclic Synthesis

机译：氮杂和碳杂迈克尔加合物是杂环合成的基础

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The present work deals with the reaction of 4-(4-bromo phenyl oxobut-2-enoic acid 1 with nitrogen and carbon nucleophiles afforded aza-and carb-Michael adducts 2, 3, 6, 9, 10, 11, 12, 13, 14 depending on the type of reagents and medium (neutral or basic) . The adducts 2 are used as a key starting materials to synthesize some hetrocycles include furanone 15, oxazinone 16 and pyridazinone 17 derivatives .The behavior of the latter compounds towards different electrophilic and nucleophilic reagents were investigated.Hydrazinoysis of the carba- Michael adduct 6 afforded tetrahydrobenzo1,2-diazapene derivatives 7, 8. The structure of the newly synthesized compounds were elucidated by elemental analysis and spectroscopic data

机译：本工作涉及4-（4-溴苯基氧代丁-2-烯酸1）与氮和碳亲核试剂的反应，得到氮杂-和碳-迈克尔加合物2、3、6、9、10、11、12、13 ，14取决于试剂和介质的类型（中性或碱性）。加合物2被用作合成某些杂环的关键原料，包括呋喃酮15，恶嗪酮16和哒嗪酮17衍生物。氨基甲酸酯加合物6的肼解反应得到四氢苯并1,2,2-二氮杂烯衍生物7、8。通过元素分析和光谱数据阐明了新合成的化合物的结构。

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《International Journal of Basic Medical Sciences and Pharmacy》 |2012年第1期|共11页
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Maher.A.EL-Hashash; Sameh. A. Rizk; and Yaser A.El-Badry;
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中图分类药学;
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Aza-and carba-Michael Adducts as Building Blocks in Heterocyclic Synthesis

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