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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Comparison of the efficacy of budesonide by nebulizer, metered dose inhaler and dry powder inhaler in chronic stable bronchial asthma
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Comparison of the efficacy of budesonide by nebulizer, metered dose inhaler and dry powder inhaler in chronic stable bronchial asthma

机译：雾化器，定量吸入器和干粉吸入器联合布地奈德治疗慢性稳定型支气管哮喘的疗效比较

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Background: The study has been performed to evaluate the efficacy of budesonide delivery by different form of devices like nebulizer, metered dose inhaler and dry powder inhaler to adult patients of chronic stable bronchial asthma. The changes in pulmonary function test parameters have been consider for evaluation. Methods: This prospective study was undertaken to assess the relative efficiency of budesonide administered from devices like nebulizer, metered dose inhaler and dry powder inhaler in adult patients of chronic stable bronchial asthma. Fifty subjects where administered budesonide (1mg) via nebulizer, budesonide (400 microgram) by metered dose inhaler and dry powder inhaler consecutively each week for four weeks under direct supervision. To analyze the effect of budesonide delivered through different devices pulmonary function test was carried out on the subject before and one hour after administration of the drug on each visit. Results: No significant difference in Peak expiratory flow rate (P=0.77), forced expiratory volume in one second (P=0.851), forced vital capacity (P=0.178) and forced expiratory volume in one second and forced vital capacity ratio (P=0.298) was seen after giving budesonide by different devices. Conclusions: Budesonide delivered by different devices (nebulizer, metered dose inhaler, and dry powder inhaler) have similar effect on lung function in patients of chronic stable bronchial asthma. In the daily clinical practice, the correct choice of an inhaler device should be related with the patient's characteristics. They may be used interchangeably depending on availability, cost and compliance of the patients.
机译：背景：已经进行了这项研究，以评估通过不同形式的装置（如雾化器，定量吸入器和干粉吸入器）布地奈德对慢性稳定支气管哮喘成年患者的疗效。肺功能测试参数的变化已被考虑进行评估。方法：这项前瞻性研究旨在评估雾化器，定量吸入器和干粉吸入器等设备对长期稳定的支气管哮喘成年患者布地奈德的相对疗效。五十名受试者每周在直接监护下连续四周通过雾化器施用布地奈德（1mg），定量吸入器布地奈德（400微克）和干粉吸入器。为了分析通过不同装置递送的布地奈德的作用，在每次就诊给药前和给药后一小时对受试者进行肺功能测试。结果：峰值呼气流速（P = 0.77），一秒钟的强迫呼气量（P = 0.851），一秒钟的强迫肺活量（P = 0.178）和一秒钟的强迫呼气量与强迫肺活量比（P）无显着差异。通过不同装置给予布地奈德后，可观察到= 0.298）。结论：通过不同装置（雾化器，定量吸入器和干粉吸入器）输送的布地奈德对慢性稳定支气管哮喘患者的肺功能具有相似的作用。在日常临床实践中，正确选择吸入器的方式应与患者的特征有关。根据患者的可用性，成本和依从性，它们可以互换使用。

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