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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Comparison of the efficacy and safety of Glimepiride and Glipizide as add-on therapy with metformin in patients of type 2 diabetes mellitus
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Comparison of the efficacy and safety of Glimepiride and Glipizide as add-on therapy with metformin in patients of type 2 diabetes mellitus

机译：格列美脲和格列吡嗪联合二甲双胍治疗2型糖尿病患者的疗效和安全性比较

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Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder carrying an enormous burden of morbidity and mortality because of its characteristic complications, many of which are preventable with strict glycaemic control. Initial management of T2DM consists of non-pharmacological interventions; it those fail, an oral anti-diabetic drug, most typically metformin, is started. Combination therapy is initiated only when monotherapy fails to achieve glycaemic control. Glipizide and glimepiride, a second and a third generation sulphonylurea respectively, are the commonest drugs added to metformin when the latter fails to achieve euglycaemia on its own. Aims and Objectives of the study were to compare the efficacy and safety of glimepiride and glipizide as add-on therapy to metformin in patients of uncontrolled T2DM. Methods: This prospective, observational and analytical study was conducted by the Department of Pharmacology among patients attending the Internal Medicine OPD of a tertiary-care hospital. Fifty patients were assigned to two groups of 25 patients each: Group A - Glimepiride + Metformin and Group B - Glipizide + Metformin. Patients were followed up for three months. Data were analysed by Student's t-test. Results: There was a significant decrease in the HbA1c, FBS and 2h-PPBS in both groups. However there was no significant difference between the two groups during the three-month period of follow-up. Conclusions: The combination of glimepiride and metformin is just as effective and safe as the combination of glipizide and metformin in patients not controlled on monotherapy with metformin.
机译：背景：2型糖尿病（T2DM）是一种慢性代谢性疾病，由于其特有的并发症而带来了极大的发病率和死亡率，其中许多并发症可以通过严格的血糖控制来预防。 T2DM的初始管理包括非药物干预;如果失败，则开始口服抗糖尿病药物，最典型的是二甲双胍。仅当单药治疗无法实现血糖控制时才开始联合治疗。当二甲双胍不能单独达到正常血糖水平时，格列吡嗪和格列美脲分别是第二代和第三代磺酰脲，是二甲双胍中最常见的药物。这项研究的目的和目的是比较格列美脲和格列吡嗪在未控制的T2DM患者中作为二甲双胍补充治疗的疗效和安全性。方法：这项前瞻性，观察性和分析性研究是由药理学部对三级医院内科OPD患者进行的。将五十名患者分为两组，每组25名：A组-格列美脲+二甲双胍和B组-格列吡嗪+二甲双胍。对患者进行了三个月的随访。数据通过学生t检验进行分析。结果：两组中的HbA1c，FBS和2h-PPBS均显着降低。但是，在三个月的随访期间，两组之间没有显着差异。结论：格列美脲和二甲双胍的联合治疗与格列吡嗪和二甲双胍的联合治疗在二甲双胍单一治疗无法控制的患者中同样有效和安全。

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