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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >A prospective study to assess the prevalence of hepatitis B infection in health care workers, voluntary blood donors, and patients with liver disorders at a tertiary care centre
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A prospective study to assess the prevalence of hepatitis B infection in health care workers, voluntary blood donors, and patients with liver disorders at a tertiary care centre

机译：在三级护理中心评估前瞻性研究以评估医护人员，自愿献血者和肝病患者的乙型肝炎感染率

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Background: Hepatitis B virus (HBV) is highly infectious when compared with human immuno-deficiency virus (HIV), even minute quantity of infected blood as little as 0.0001 ml can transmit infection. A number of the routine therapeutic, diagnostic, prophylactic invasive procedures can spread HBV infection. The study was planned to assess the prevalence of hepatitis B surface antigen in health care workers, voluntary blood donors, and patients with liver disorders. Methods: The study was a cross sectional study carried out among 90 subjects during a period of one year in Indira Gandhi Medical College and Hospital, Shimla. These 90 subjects consisted of 30 patients with liver disorder, 30 health care workers and 30 voluntary blood donors. The blood samples were collected and sent for detection of HBsAg by ELISA. Results: Majority of the subjects 47 (52.2%) belonged to the age group of 21-30 years. Among voluntary blood donors, 90% were males. 64.4% of the subjects belonged to urban areas. 50% of the rural subjects were having liver disorders. Liver disorder was more common (71.5%) among heterosexual high risk behaviour subjects compared to only 25.7% with no high risk behaviour. Seropositivity was found highest among patients with liver disorder (66.7%) followed by health care workers (20%). Overall, the seropositivity was 28.9%. Conclusions: Patients with liver disorders especially chronic hepatitis were mostly seropositive. Among health care workers, being a doctor was a significant risk factor for acquiring hepatitis B infection. Thus, it is advised that all health care workers should be immunized for hepatitis B.
机译：背景：与人类免疫缺陷病毒（HIV）相比，乙型肝炎病毒（HBV）具有很高的传染性，即使微量的受感染血液只有0.0001 ml也可以传播感染。许多常规的治疗，诊断，预防性侵入性程序均可传播HBV感染。计划进行这项研究以评估卫生保健工作者，自愿献血者和肝病患者中乙型肝炎表面抗原的患病率。方法：这项研究是一项横断面研究，为期一年，在西姆拉的英迪拉·甘地医学院和医院对90名受试者进行了研究。这90名受试者包括30名肝病患者，30名医护人员和30名自愿献血者。收集血样并通过ELISA发送以检测HBsAg。结果：受试者的绝大多数（21岁至30岁）为47岁（52.2％）。在自愿献血者中，男性占90％。 64.4％的受试者属于城市地区。 50％的农村受试者患有肝病。在异性恋高危行为受试者中，肝病更为普遍（71.5％），而无高危行为的患病率仅为25.7％。血清阳性在肝病患者中最高（66.7％），其次是医护人员（20％）。总体而言，血清阳性率为28.9％。结论：患有肝病，尤其是慢性肝炎的患者大多呈血清反应阳性。在卫生保健工作者中，当医生是获得乙型肝炎感染的重要危险因素。因此，建议所有医护人员应接种乙肝疫苗。

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