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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Phytochemical evaluation and pharmacological screening of ethanolic and aqueous leaf extracts of Pupalia lappacea for antihyperlipidemic and antihyperglycemic activities in alloxan induced diabetic Albino wistar rats
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Phytochemical evaluation and pharmacological screening of ethanolic and aqueous leaf extracts of Pupalia lappacea for antihyperlipidemic and antihyperglycemic activities in alloxan induced diabetic Albino wistar rats

机译：番木瓜乙醇和水提取物对四氧嘧啶致糖尿病白化病wistar大鼠降血脂和降血糖活性的植物化学评价和药理筛选

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Background: Diabetes is associated with damage to the liver, pancreas and kidney. The damage may vary among patients. This study assessed the hypoglycaemic and antihyperlipidemic activities of leaves ethanolic and aqueous extracts of Pupalia lappacea e in alloxan induced diabetic albino wistar rats. Methods: There were Fifty four rats divided into nine groups containing six rats each. Group 1 consists of normal rats that were given only normal saline and served as a control group. Group 2 consists of normal rats that were given alloxan monohydrate (150mg/kg b.w). Group 3 consists alloxan induced diabetic rats that were given daily sterile solution. glibenclamide+simvastatin (5mg/kg) Group 4 consists of alloxan induced diabetic rats that were given daily sterile solution, AEPL extract (100mg/kg). Group 5 consists of alloxan induced diabetic rats that were given daily sterile solution, drug extract AEPL (200mg/kg). Group 6 consists of alloxan induced diabetic rats that were given daily sterile solution, drug extract AEPL (400mg/kg) Group 7 consists of alloxan induced diabetic rats that were given daily sterile solution, drug extract EEPL (100mg/kg), Group 8 consists of alloxan induced diabetic rats that were given daily sterile solution, drug extract EEPL (200mg/kg) Group 9 consists of alloxan induced diabetic rats that were given daily sterile solution, drug extract EEPL (400mg/kg respectively for 21days by an intragastric tube with free access of food and water. Results: Chemical composition of the plant was estimated by GCMS technique several biochemical parameters were assessed. Oral administration of the extract resulted in significant reduction in mean values of blood glucose, triglycerides, total cholesterol, cholesterol ratio, LDL, VLDL, accompanied by increase in the mean value of the HDL in diabetic rats and histopathology of liver, pancreas, and kidney showed significant changes. Conclusions: The effects produced were closely similar to standard antidiabetic and antihyperlipidemic drug. It can thus be concluded that the ethanolic and aqueous extract of Pupalia lappacea e exhibit antihyperlipidemic and antihyperglycemic activities in alloxan induced diabetes in rats.
机译：背景：糖尿病与肝脏，胰腺和肾脏的损害有关。损害可能因患者而异。本研究评估了四氧嘧啶诱导的糖尿病白化病wistar大鼠叶片Pupalia lappacea e乙醇和水提取物的降血糖和降血脂活性。方法：54只大鼠分为9组，每组6只。第1组由仅给予生理盐水并作为对照组的正常大鼠组成。第2组由给予四水合四氧嘧啶（150mg / kg b.w）的正常大鼠组成。第3组包括每天给予无菌溶液的四氧嘧啶诱导的糖尿病大鼠。格列本脲+辛伐他汀（5mg / kg）第4组由四氧嘧啶诱导的糖尿病大鼠每日给予无菌溶液AEPL提取物（100mg / kg）。第5组由四氧嘧啶诱导的糖尿病大鼠组成，每天给予无菌溶液，药物提取物AEPL（200mg / kg）。第6组由每天给予无菌溶液的四氧嘧啶诱导的糖尿病大鼠，药物提取物AEPL（400mg / kg），第7组由每天给予无菌溶液的四氧嘧啶诱导的糖尿病大鼠，药物提取物EEPL（100mg / kg），第8组包括每天给予无菌溶液的四氧嘧啶诱导的糖尿病大鼠，其药物提取物EEPL（200mg / kg）第9组由经胃内插管的大鼠每日给予无菌溶液，药物提取物EEPL（400mg / kg，分别为21天）组成结果：通过GCMS技术估算了植物的化学成分，评估了一些生化参数，口服提取物可显着降低血糖，甘油三酸酯，总胆固醇，胆固醇比，LDL的平均值，VLDL，伴随着糖尿病大鼠HDL平均值的增加，肝脏，胰腺和肾脏的组织病理学发生了显着变化。使用方法：产生的作用与标准的抗糖尿病药和降血脂药极为相似。因此可以得出结论，Pupalia lappacea e的乙醇提取物和水提取物在四氧嘧啶诱发的大鼠糖尿病中具有抗高血脂和抗高血糖的活性。

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