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首页> 外文期刊>International Journal of Biochemistry Research & Review >Protective Effect of Dorema glabrum on Induced Oxidative Stress by Diazinon in Hippocampus of Rat
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Protective Effect of Dorema glabrum on Induced Oxidative Stress by Diazinon in Hippocampus of Rat

机译：马齿Dor对大鼠海马地嗪酮诱导的氧化应激的保护作用。

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Introduction : Diazinon (DZN) administration produces lipid peroxidation as an indicator of oxidative stress in the brain. Some medicinal plants such as Dorema glabrum has antioxidant properties, so can be used as an antioxidant that may protect neurons from oxidative stress. The aim of present study was to investigate the effect of D. glabrum against DZN-induced oxidative stress in hippocampus. Methods : Twenty-four adult male Wistar rats were used in this study. The rats randomly were divided into four groups including a control group, and two groups received different doses of D. glabrum (40 and 80 mg/kg) as pre-treatment for 21 days with DZN (100 mg/Kg) that was injected intraperitoneally (ip) in last day of D. glabrum usage, and one group received only DZN. Thiobarbituric acid reactive substances (TBARS), which are the indicators of lipid peroxidation, and the activities of antioxidant enzymes (glutathione peroxidase, superoxide dismutase and catalase) were determined in the ratssup? /suphippocampus. Results: Administration of DZN significantly increased TBARS levels and superoxide dismutase activity and decreased glutathione peroxidase activity but there were no significant changes in catalase activity in the hippocampus. Combined D. glabrum and DZN treatment, caused a significant increase in glutathione peroxidase, a significant decrease of TBARS and a significant decrease in superoxide dismutase and again no significant changes in catalase activity in the rats’ hippocampus when compared to the rats treated with DZN. Conclusion: Our study demonstrated that D. glabrum had an amelioratory effect on oxidative stress induced by DZN.
机译：简介：二嗪农（DZN）给药会产生脂质过氧化作用，这是大脑中氧化应激的指标。一些药用植物（例如Dorema glabrum）具有抗氧化特性，因此可用作抗氧化剂，可以保护神经元免受氧化应激。本研究的目的是研究延胡索菌对DZN诱导的海马氧化应激的影响。方法：采用24只成年雄性Wistar大鼠。将大鼠随机分为四组，包括对照组，并且两组接受不同剂量的百日草（40和80 mg / kg）进行21天的腹腔注射DZN（100 mg / Kg）预处理（ip）在D. glabrum使用的最后一天，而一组只收到DZN。确定了大鼠脂质过氧化的指标硫代巴比妥酸反应性物质（TBARS），并测定了大鼠抗氧化酶的活性（谷胱甘肽过氧化物酶，超氧化物歧化酶和过氧化氢酶）。 海马。结果：DZN的使用显着增加了TBARS水平和超氧化物歧化酶活性，并降低了谷胱甘肽过氧化物酶活性，但海马中的过氧化氢酶活性没有明显变化。与用DZN处理的大鼠相比，组合的D. glabrum和DZN处理引起了大鼠谷胱甘肽过氧化物酶的显着增加，TBARS的显着降低和超氧化物歧化酶的显着降低，并且海马中的过氧化氢酶活性也没有明显变化。结论：我们的研究表明，哈密瓜对DZN诱导的氧化应激有改善作用。

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