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首页> 外文期刊>International Journal of Biochemistry Research & Review >Amelioratory Effect of Dorema glabrum on Diazinon-Induced Oxidative Stress in Rat Liver
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Amelioratory Effect of Dorema glabrum on Diazinon-Induced Oxidative Stress in Rat Liver

机译：Dorema glabrum对二嗪农诱导的大鼠肝脏氧化应激的改善作用

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Introduction: A wide number of pesticides, including highly persistent organophosphorous compounds, such as diazinon (DZN) have deteriorating effect on fauna and flora by inducing oxidative stress. DZN induces cell damage by producing free radicals and reactive oxygen species. In addition to the antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) activities in the liver tissue, reactive oxygen species (ROS) have been employed in the toxicity of organophosphate insecticides (OPIs) and the level of lipid peroxidation was analyzed. The present study was designed to explore the ameliorative characteristics of D. glabrum against the subchronic impact of DZN on such oxidative damage markers as lipid peroxidation (LPO) and the antioxidant defense system (ADS) existing in the liver of male Wistar rats. Methods: Twenty-four adult male Wistar rats were used in this study. The rats randomly divided into four groups including a control group, and three experimental groups. Two of three experimental groups received different doses of D. glabrum (40 and 80 mg/kg) as pre-treatment for 21 days along with DZN (100 mg/kg) that injected intraperitoneally in the last day of D. glabrum usage, and one group received only DZN (100 mg/kg). Results: Compared with the control group, we noticed significantly high levels of LPO and the low antioxidant defenses, like free radical scavenging enzymes viz., catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) in DZN-treated group. Considering the hepatic toxicity of DZN, evident changes were also noticed in endogenous antioxidant enzyme along with high LPO levels. In rats supplemented with D. glabrum as well as treated with DZN, hepatic specific marker enzymes were restored to normalcy which otherwise was lowered in the DZN-treated rats. The obtained results revealed that the oxidative stress of DZN-treated rats is diminished when D. glabrum is co-treated with DZN. This co-treatment may also act as a putative protective agent against DZN-induced liver tissue injury.
机译：简介：多种农药，包括高度持久的有机磷化合物，例如二嗪农（DZN），会通过诱导氧化应激而对动植物造成恶化的影响。 DZN通过产生自由基和活性氧来诱导细胞损伤。除了抗氧化酶，例如过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GPx），肝组织中的超氧化物歧化酶（SOD）活性，活性氧（ROS），还被用于有机磷杀虫剂（OPIs）和分析脂质过氧化的水平。本研究旨在探讨延胡索菌对DZN的亚慢性影响对雄性Wistar大鼠肝脏中脂质过氧化（LPO）和抗氧化防御系统（ADS）等氧化损伤标志物的改善作用。方法：采用24只成年雄性Wistar大鼠。将大鼠随机分为四组，包括对照组和三个实验组。三个实验组中的两个接受了不同剂量的D. glabrum（40和80 mg / kg）进行为期21天的预处理，同时接受DZN（100 mg / kg）的腹腔注射D. glabrum的最后一天，以及一组仅接受DZN（100 mg / kg）。结果：与对照组相比，我们发现DZN治疗组的LPO水平显着较高，而抗氧化防御能力却很低，例如自由基清除酶，过氧化氢酶（CAT），超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）。 。考虑到DZN的肝毒性，内源性抗氧化剂和高LPO含量也发生了明显变化。在补充了禾本科和用DZN处理的大鼠中，肝特异性标记酶恢复正常，否则在DZN处理的大鼠中降低。获得的结果表明，当D.Glabrum与DZN共同处理时，DZN处理的大鼠的氧化应激降低。这种共同治疗也可以作为针对DZN诱导的肝组织损伤的假定保护剂。

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