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首页> 外文期刊>International Journal of Biochemistry Research & Review >Phytochemistry and Antimicrobial Activity of Extracts from Medicinal Plant Olea africana and Olea europea
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Phytochemistry and Antimicrobial Activity of Extracts from Medicinal Plant Olea africana and Olea europea

机译：药用植物非洲油橄榄和欧洲油橄榄提取物的植物化学和抑菌活性

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Increase in prevalence of resistant microorganisms especially to synthetic drugs, has necessitated the need to search for new bioactive compounds having natural origin. Thus it was essential to determine the antibacterial activity of hexane, dichloromethane, ethyl acetate and methanol extracts of Olea africana and Olea europea. Phytochemical investigation of both Olea africana and O. europea extracts indicated the presence alkaloids, flavones, flavanoids and tannins. Olea africana leaves extracts afforded two triterpenoids namely erythrodiol and uvaol which were obtained through repeated column chromatography. The compounds were characterized using Nuclear Magnetic Resonance (NMR) spectroscopy, MS spectroscopy and by comparison with literature values. The isolated triterpenoids exhibited moderate antibacterial activity whereas crude extracts exhibited relatively high antibacterial activity against Gram positive bacterial strains; methanol extracts inhibited growth and showed 12.4 mm zone of inhibition against Staphylococcus aureus, Erythrodiol exhibited higher antibacterial activity than uvaol against Gram positive bacteria Staphylococcus aureus with zones of inhibition of 5.2 mm and 5.0 mm respectively. None of the pure compounds showed significant activity against Gram negative bacteria Escherichia coli. The results gives a scientific validity and credence to the ethno-medicinal use of this medicinal plant as a chewing stick.
机译：抗药性微生物，特别是对合成药物的耐药性的增加，需要寻找具有天然来源的新的生物活性化合物。因此，确定非洲油橄榄和欧洲油橄榄的己烷，二氯甲烷，乙酸乙酯和甲醇提取物的抗菌活性至关重要。非洲油橄榄和欧洲油菜提取物的植物化学研究表明存在生物碱，黄酮，类黄酮和丹宁酸。非洲油橄榄叶提取物提供了两个三萜类化合物，即赤藓糖醇和丁香酚，它们是通过重复柱色谱法获得的。使用核磁共振（NMR）光谱，MS光谱对化合物进行表征，并与文献值进行比较。分离出的三萜类化合物表现出中等的抗菌活性，而粗提物表现出对革兰氏阳性细菌菌株的相对高的抗菌活性。甲醇提取物抑制生长，并显示出对金黄色葡萄球菌的抑制作用区为12.4 mm。与丁香酚相比，赤藓糖醇对革兰氏阳性菌金黄色葡萄球菌显示出更高的抑菌活性，分别为5.2 mm和5.0 mm。没有一种纯化合物对革兰氏阴性菌大肠杆菌具有显着活性。结果为该药用植物作为口香棒的民族药用用途提供了科学依据和信誉。

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