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首页> 外文期刊>International Journal of Biochemistry Research & Review >Reduction of Plasma Adiponectin in Egyptian ObeseChildren with Nonalcoholic Fatty Liver Disease
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Reduction of Plasma Adiponectin in Egyptian ObeseChildren with Nonalcoholic Fatty Liver Disease

机译：非酒精性脂肪肝儿童埃及肥胖儿童血浆脂联素的减少

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Background: Obesity, insulin resistance and dyslipidemia are the most significant risk factors of non-alcoholic fatty liver disease (NAFLD) in children, and a major cause of liver-related morbidity. The aim of this study was to evaluate the serum levels of adiponectin, leptin and fasting insulin in obese children with NAFLD to explore the role of adiponectin in the pathogenesis of this disease.Materials and Methods: The fasting serum levels of adiponectin, leptin, glucose, insulin, ALT, AST, total bilirubin, direct bilirubin, albumin, alkaline phosphatase, creatinine, cholesterol, triglycerides, HDL, LDL, GGT and CRP were measured in a group of 50 NAFLD children after making ultrasonography and 40 other participants were considered as a control group with comparable age, sex and body-mass index.Results: Plasma adiponectin was found significantly low in NAFLD children than its level in control group (3.23± 2.5 vs 11.0 ± 2.95 ng/dl). Moreover, NAFLD group had significantly higher insulin resistance, fasting insulin 11.4± 4.9 vs 4.7±3.1 mu/l levels in comparison with control group. Regarding serum leptin, there was no significant difference. An inverse correlation was observed between adiponectin and homeostatic model assessment (HOMA-IR), fasting insulin, leptin, triglycerides, ALT, AST, GGT and BMI. Conclusion: This data supports a role for low circulating adiponectin value in the pathogenesis of NAFLD and its association with insulin resistance.
机译：背景：肥胖，胰岛素抵抗和血脂异常是儿童非酒精性脂肪性肝病（NAFLD）的最重要危险因素，并且是肝脏相关发病率的主要原因。这项研究的目的是评估肥胖的NAFLD儿童的血清脂联素，瘦素和空腹胰岛素水平，以探讨脂联素在该病发病机理中的作用。材料与方法：空腹血清脂联素，瘦素，葡萄糖在进行超声检查后，对50例NAFLD儿童进行了胰岛素，ALT，AST，总胆红素，直接胆红素，白蛋白，碱性磷酸酶，肌酐，胆固醇，甘油三酸酯，HDL，LDL，GGT和CRP的测定，其他40名参与者结果：发现NAFLD患儿血浆脂联素明显低于对照组（3.23±2.5 vs 11.0±2.95 ng / dl）。此外，NAFLD组的胰岛素抵抗明显高于对照组，空腹胰岛素为11.4±4.9 vs 4.7±3.1 mu / l。关于血清瘦素，没有显着差异。脂联素与稳态模型评估（HOMA-IR），空腹胰岛素，瘦素，甘油三酸酯，ALT，AST，GGT和BMI之间呈负相关。结论：该数据支持低循环脂联素值在NAFLD的发病机制中及其与胰岛素抵抗的关系。

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