• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Biochemistry Research & Review >Contraceptive Effect of Ethanolic Extract ofDioscorea villosa Tuber on Reproductive Hormonesof Female Wistar Rats
【24h】

Contraceptive Effect of Ethanolic Extract ofDioscorea villosa Tuber on Reproductive Hormonesof Female Wistar Rats

机译：七叶树乙醇提取物对雌性Wistar大鼠生殖激素的避孕作用。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The contraceptive effect of oral administration of ethanolic extract of Dioscorea villosa tuber for thirty days on reproductive hormones of female albino rats was investigated. Twenty four female albino rats weighing 150-220g were completely randomized into four groups (A-D) comprising six rats each. Animals in Group A (control) were administered 0.5ml of distilled water. Animals in groups B, C and D received 100, 200 and 400mg/kg body weight of ethanolic extract of Dioscorea villosa tuber respectively for 30 consecutive days. Preliminary phytochemical screening of ethanolic extract of Dioscorea villosa tuber revealed the presence of alkaloids, saponins, flavonoids and cardiac glycosides. The extract at all tested doses decreased serum luteinizing hormone (LH) levels, although this effect was statistically significant only at 100mg/kg body weight (p<0.05). The extract at all doses significantly (p<0.05) decreased the concentration of progesterone in the serum of the animals. A decrease in serum estradiol levels was observed only in animals that received 100 and 200mg/kg body weight of the extract while the 400mg/kg body weight of the extract did not significantly (p>0.05) affect the serum estradiol concentration when compared with the distilled water treated control animals. Serum levels of follicle stimulating hormone (FSH) increased following treatment in a dose-dependent manner, and this effect was statistically significant only at 400mg/kg body weight (p<0.05). These alterations in female rat reproductive hormones by the extract are hormonal imbalance and would have adverse effect on maturation and ovulation of follicles. Consequently, the extract may impair fertility and pregnancy in female rats. Therefore, the ethanolic extract of Dioscorea villosa tuber may be explored as a female contraceptive.
机译：研究了薯Di薯片乙醇提取物口服三十天对雌性白化病大鼠生殖激素的避孕作用。将二十四只体重150-220g的雌性白化病大鼠完全随机分为四组（A-D），每组六只。给A组的动物（对照）施用0.5ml的蒸馏水。 B，C和D组的动物连续30天分别接受100、200和400mg / kg体重的薯Di的​​乙醇提取物。薯Di块茎乙醇提取物的初步植物化学筛选显示存在生物碱，皂角苷，类黄酮和强心苷。在所有测试剂量下，提取物均降低了血清促黄体生成激素（LH）水平，尽管这种作用仅在100mg / kg体重时才具有统计学意义（p <0.05）。所有剂量的提取物均显着（p <0.05）降低了动物血清中孕酮的浓度。仅与接受了100和200mg / kg体重提取物的动物相比，血清雌二醇水平降低，而与接受提取物相比，400mg / kg体重提取物对血清雌二醇浓度的影响不显着（p> 0.05）。蒸馏水处理过的对照动物。治疗后，血清中的促卵泡激素（FSH）水平呈剂量依赖性增加，且仅在400mg / kg体重时此作用具有统计学意义（p <0.05）。提取物对雌性大鼠生殖激素的这些改变是荷尔蒙失调，会对卵泡的成熟和排卵产生不利影响。因此，提取物可能会损害雌性大鼠的生育能力和妊娠。因此，薯Di的乙醇提取物可作为女性避孕药。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号