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首页> 外文期刊>International Journal of Biotechnology and Molecular Biology Research >HLA-DQA1 and DQB1 genotyping in individuals with family history of gastritis
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HLA-DQA1 and DQB1 genotyping in individuals with family history of gastritis

机译：有胃炎家族史的人的HLA-DQA1和DQB1基因分型

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The objective was to study HLA-DQA1 and HLA-DQB1 genotyping in individuals (patients and controls) with family history of gastritis. This study was carried out in College of Medicine, University of Basrah. HLA-DQA1 and HLA-DQB1 genotyping was done in College of Medicine, University of Manitoba, and Winnpeg, Canada during the period from 17th of April 2009 to 15th of July 2010. A total of 100 patients (41 males and 59 females) and a total of 30 controls (18 males and 12 females) were included in this study. A significant decreased frequency of DQA1*0201 allele was found in individuals (patients + controls) with family history of gastritis with a strong association (odds ratio = 4.57), as compared with individuals without family history of gastritis. Significant increased alleles frequencies of DQA1*0402 and DQB1*0402 were found in individuals with family history of gastritis, but with weak association (odds ratios, 0.16 and 0.20 respectively), as compared with individuals without family history of gastritis.
机译：目的是研究具有胃炎家族史的个人（患者和对照）的HLA-DQA1和HLA-DQB1基因型。这项研究是在巴士拉大学医学院进行的。 HLA-DQA1和HLA-DQB1基因分型是在2009年4月17日至2010年7月15日期间，在曼尼托巴大学和加拿大温佩格医学院进行的。共有100例患者（男41例，女59例）和本研究共纳入30位对照（男性18位，女性12位）。与无胃炎家族史的个体相比，在有胃炎家族史的个人（患者+对照组）中，DQA1 * 0201等位基因的频率显着下降（关联比= 4.57）。与没有胃炎家族史的个体相比，在有胃炎家族史的个体中发现DQA1 * 0402和DQB1 * 0402的等位基因频率显着增加，但关联性较弱（比值分别为0.16和0.20）。

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