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Role of Locally Synthesised Protein in Long Term Memory - An Analytical Approach

机译:本地合成蛋白在长期记忆中的作用-分析方法

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Permanent alteration in the structure and number of synapses involves new protein synthesis and assemblage of new memory circuits resulting changes in electrical activity of specific regions of the brain due to different learning experiences. Injections of protein inhibitor in the temporal lobe of mice led to the fact that learning is effective in long-term memory (LTM). Studies of long term potentiation (LTP) and long term depression (LTD) in mammalian brains resulted in two distinct phases- the early one (typically lasting 1-3 hours) is independent of new protein synthesis and the late one (typically lasting more than 8 hours) depends on new protein synthesis. This paper focuses on developing an Analytical Approach for mathematical analysis of these experimental findings basing on the role of protein vibrations in learning and memory with the assumption that dissociation or association of the number of amino acid molecules are required for synthesis of new protein responsible for LTM.
机译:突触的结构和数量的永久改变涉及新的蛋白质合成和新的记忆电路的组装,由于不同的学习经历,导致大脑特定区域的电活动发生变化。在小鼠颞叶注射蛋白质抑制剂可导致这样的事实,即学习对长期记忆(LTM)有效。对哺乳动物大脑的长期增强(LTP)和长期抑郁(LTD)的研究导致了两个不同的阶段-早期阶段(通常持续1-3小时)独立于新蛋白质的合成,晚期阶段(通常持续超过3小时) 8小时)取决于新的蛋白质合成。本文着重于基于蛋白质振动在学习和记忆中的作用,并假设氨基酸分子数目的解离或缔合是合成负责LTM的新蛋白质所必需的假设,为这些实验结果的数学分析开发一种分析方法。 。

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