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首页> 外文期刊>International Journal of Biophysics >Role of Protein Vibration in Anti-Alzheimer’s Effect of Ashwagandha (Withania Symnifera) - An Analytical Approach
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Role of Protein Vibration in Anti-Alzheimer’s Effect of Ashwagandha (Withania Symnifera) - An Analytical Approach

机译：蛋白质振动在Ashwagandha（Withania Symnifera）抗阿尔茨海默氏病中的作用-一种分析方法

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摘要

Alzheimer normally occurs in old age people. This results in memory loss and cognitive decline. The patient at his crucial stage losses almost his physical fitness. The disease has got no complete cure till the death. It is due to aggregation of either a different tau isomers or different constituents of Aβ – amyloid protein. A good number of scholars are now – a – days conducting a study on therapeutic aspects of Ashwagandha – a traditional Indian herb. Empirical studies also reflect on a successful implication of Ashwagandha root extract on Alzheimer’s affected mice. But the mechanism of activity of the extract has rarely been explained. The present paper focuses on the mechanism of disaggregation of aggregated protein by HSP – 70 induced by the extract of Ashwagandha and also on the removal technique of the disaggregated fragments with the help of LRP receptor. The problem has been viewed in the context of Protein Vibration – a hypothetical approach of the physical characteristics of protein.
机译：老年痴呆症通常发生在老年人中。这导致记忆丧失和认知下降。病人在关键阶段几乎失去了身体健康。直到死亡，这种疾病还没有完全治愈。这是由于不同的tau异构体或Aβ–淀粉样蛋白的不同成分的聚集所致。现在，很多学者正在对传统印度草药Ashwagandha的治疗方面进行研究。经验研究还反映了非洲醉茄根提取物对阿尔茨海默氏症小鼠的成功暗示。但是提取物的活性机理很少得到解释。本文着重探讨了非洲醉茄提取物诱导的HSP-70聚集蛋白的分解机理，以及借助LRP受体去除聚集片段的技术。已经在蛋白质振动的背景下研究了该问题，这是蛋白质物理特性的一种假设方法。

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