Activation of Heat Shock Protein Induced by Curcumin to Prevent Huntington Disease- an Analytical Approach in the Context of Protein Vibration

Brajagopal Majumder

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Activation of Heat Shock Protein Induced by Curcumin to Prevent Huntington Disease- an Analytical Approach in the Context of Protein Vibration

机译：姜黄素诱导的热休克蛋白的活化以预防亨廷顿病-一种在蛋白振动中的分析方法

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Depending on aggregate size, amino acid sequence and degree of misfolding, protein aggregates are disaggregated by Heat Shock Proteins (HSPs). Natural products can induce SHPs. Curcumin- the chemical constituent of turmeric paste/powder is now being considered as the inducer of HSPs which are able to reduce aggregates of glutamine amino acids and can also modulate the signaling pathway of small fragments of glutamine molecules. The molecular mechanism of disaggregation of aggregated glutamines has been considered from the view point of protein vibration which is expected to be happened either due to inherent electrostatic potential of the cell or due to external stimuli. Here we have discussed the current knowledge on the role of HSP induced by curcumin particularly with respect to Huntington diseases (HD) in the context of Protein Vibration Approach.

机译：根据聚集体的大小，氨基酸序列和错误折叠的程度，蛋白质聚集体会通过热激蛋白（HSP）分解。天然产物可以诱导小水电。姜黄素-姜黄糊/粉的化学成分，现在被认为是HSP的诱导剂，它能够减少谷氨酰胺氨基酸的聚集，并且还可以调节谷氨酰胺分子小片段的信号传导途径。从蛋白质振动的观点考虑了聚集的谷氨酰胺解聚的分子机理，预期该振动是由于细胞固有的静电势或由于外部刺激而发生的。在这里，我们已经讨论了有关姜黄素诱导的HSP在蛋白质振动方法中特别是在亨廷顿病（HD）方面的作用的当前知识。

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《International Journal of Biophysics》 |2018年第1期|共8页
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Brajagopal Majumder;
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2. Hyperthermia, inducing pancreatic heat-shock proteins, fails to prevent cerulein-induced stress kinase activation. [J] . Metzler W, Hofken T, Weber H, Pancreas . 1999,第2期

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3. Expression of the activating transcription factor 3 prevents c-Jun N-terminal kinase-induced neuronal death by promoting heat shock protein 27 expression and Akt activation. [J] . Nakagomi S, Suzuki Y, Namikawa K, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2003,第12期

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4. Mining Heat Stress Induced Genes Encoding Heat Shock Proteins (HSPs) and Heat Stress Transcription Factors (HSFs) in Strawberry (Fragaria x ananassa) [C] . Lee-Fong Lin, Shih-Yi Liao, Jui-Hung Yen, International Conference on Mechanics and Control Engineering . 2014

机译：采矿热应激诱导在草莓（Fragaria x ananassa）中编码热休克蛋白（HSP）和热应激转录因子（HSF）的热应激诱导基因
5. Heat shock protein 70 inhibits heat -induced apoptosis by preventing proteasomal degradation of the anti-apoptotic Bcl-2 family protein Mcl-1 [D] . Stankiewicz, Adam Robert 2008

机译：热休克蛋白70通过防止抗凋亡的Bcl-2家族蛋白Mcl-1的蛋白酶体降解来抑制热诱导的细胞凋亡。
6. Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation [O] . Lakshmi Bhagat, Vijay P. Singh, Antti J. Hietaranta, 2000

机译：热休克蛋白70通过防止细胞内胰蛋白酶原的活化来防止胰泌素诱导的胰腺细胞损伤
7. Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation [O] . Bhagat, Lakshmi, Singh, Vijay P., Hietaranta, Antti J., 2000

机译：热休克蛋白70通过防止细胞内胰蛋白酶原的活化来防止胰泌素诱导的胰腺细胞损伤
8. Expression and Function of Heat Shock Proteins in the Mammalian Gut During Experimentally Induced Hypoxia and Exogenous Stress [R] . Murashov, A. K. 1999

机译：热休克蛋白在哺乳动物肠道实验性缺氧和外源性应激过程中的表达和功能

Activation of Heat Shock Protein Induced by Curcumin to Prevent Huntington Disease- an Analytical Approach in the Context of Protein Vibration

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