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首页> 外文期刊>International Journal of Breast Cancer >The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study
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The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study

机译：局部治疗对非转移性炎性乳腺癌的影响：一项基于人群的研究

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Background. Inflammatory breast cancer (IBC) is a rare but most aggressive breast cancer subtype. The impact of locoregional therapy on survival in IBC is controversial. Methods. Patients with nonmetastatic IBC between 1988 and 2013 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry. Results. We identified 7,304 female patients with nonmetastatic inflammatory breast cancer (IBC) who underwent primary tumor surgery. Most patients underwent total mastectomy with only 409 (5.6%) undergoing a partial mastectomy. In addition, 4,559 (62.4%) were also treated with radiation therapy. The patients who underwent mastectomy had better survival compared to partial mastectomy (49% versus 43%, = 0.003). The addition of radiation therapy was also associated with improved 5-year survival (55% versus 40%, 0.001). Multivariate analysis showed that black race HR (1.22, 95% CI 1.18–1.35), ER negative status (HR 1.22, 95% CI 1.16–1.28), and higher grade (HR 1.14, 95% CI 1.07–1.20) were associated with poor outcome. Cox proportional hazards model showed that total mastectomy (HR 0.75, 95% CI 0.65–0.85) and radiation (HR 0.64, 95% CI 0.61–0.69) were associated with improved survival. Conclusions. Optimal locoregional therapy for women with nonmetastatic IBC continues to be mastectomy and radiation therapy. These data reinforce the prevailing treatment algorithm for nonmetastatic IBC.
机译：背景。炎性乳腺癌（IBC）是一种罕见但最具侵略性的乳腺癌亚型。局部区域疗法对IBC生存的影响是有争议的。方法。在监测，流行病学和最终结果（SEER）注册表中确定了1988年至2013年之间患有非转移性IBC的患者。结果。我们确定了7,304例接受原发性肿瘤手术的非转移性炎性乳腺癌（IBC）女性患者。大多数患者进行了全乳切除，只有409例（5.6％）接受了部分乳房切除术。此外，还有4559（62.4％）人接受了放射治疗。与部分乳房切除术相比，接受乳房切除术的患者存活率更高（49％比43％，= 0.003）。增加放疗还可以改善5年生存率（55％比40％，<0.001）。多变量分析显示，黑人种族HR（1.22，95％CI 1.18-1.35），ER阴性状态（HR 1.22，95％CI 1.16-1.28）和较高等级（HR 1.14，95％CI 1.07-1.20）相关。结果差。 Cox比例风险模型显示，全乳房切除术（HR 0.75，95％CI 0.65-0.85）和放射线（HR 0.64，95％CI 0.61-0.69）与存活率提高相关。结论。对于非转移性IBC妇女的最佳局部疗法仍然是乳房切除术和放射疗法。这些数据加强了非转移性IBC的主流治疗算法。

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