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首页> 外文期刊>Annals of surgical oncology >Improved Locoregional Control in a Contemporary Cohort of Nonmetastatic Inflammatory Breast Cancer Patients Undergoing Surgery
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Improved Locoregional Control in a Contemporary Cohort of Nonmetastatic Inflammatory Breast Cancer Patients Undergoing Surgery

机译：改善了在接受手术的现代炎性乳腺癌患者的当代队列课程

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Abstract Background Inflammatory breast cancer (IBC) is an aggressive form of breast cancer characterized by rapid progression and early metastatic dissemination. The purpose of this study was to assess contemporary rates of local regional recurrence (LRR) in the era of trimodality therapy for nonmetastatic IBC and identify risk factors leading to local failure. Methods A total of 114 patients with nonmetastatic IBC receiving trimodality therapy (neoadjuvant chemotherapy, surgery, and radiation therapy) were identified from a prospectively collected database from 2007 to 2015 and outcomes analyzed. Results Median age at diagnosis was 52?years, and the median follow-up was 3.6?years. Sixty-three (55%) patients presented with N2 IBC, and 52 patients (45%) presented with N3 IBC. Local regional recurrence was observed during follow-up for four patients; 25 died, and 85 were censored at last follow-up. Surgical margins were negative in 99% of patients ( n ?=?113). The 2-year probability of LRR was 3.19% (95% confidence interval 1.03–9.90%). Five-year overall survival for this cohort was 69.14%. Improvement in disease-free survival was seen among patients with HER2+ subtype, clinical stage IIIB, complete or partial radiologic response to neoadjuvant therapy, pathologic complete response, and lower nodal burden on presentation. Conclusions Locoregional recurrences were rare at a median of 3.6?years follow-up in a contemporary cohort of IBC patients treated with trimodality therapy. Although longer follow-up is needed, aggressive surgical resection to negative margins in the frame of trimodality therapy with curative intent can lead to LRR rates that mirror non-IBC rates.
机译：摘要背景炎症乳腺癌（IBC）是一种积极的乳腺癌形式，其特征在于快速进展和早期转移性传播。本研究的目的是评估非更换IBC剪裁治疗时代的当代局部区域复发（LRR）的当代率，并确定导致局部失败的危险因素。方法从2007年至2015年从2007年到2015年的数据库中鉴定了114例非容性IBC接受染色体治疗（Neoadjuvant化疗，手术和放射疗法）的114例患者。分析结果。结果诊断中位年龄为52岁？年龄，中位随访时间为3.6？多年。六十三（55％）患者患有N2 IBC，52名患者（45％）呈现N3 IBC。在四名患者的随访期间观察到局部区域复发; 25死亡，最后一次后续审查了85次。 99％的患者的手术边缘是阴性的（n？= 113）。 LRR的2年概率为3.19％（95％置信区间1.03-9.90％）。此队列的五年整体生存率为69.14％。 HER2 +亚型，临床阶段IIIB，临床阶段IIIB，患者对新辅助治疗，病理完全反应以及呈现呈下节点负担的患者，患有无病生存期间的改善。结论在3.6岁的中位数中位于3.6岁的IBC患者的中位数，稀有的患者罕见的患者罕见。虽然需要更长的随访，但是致氮化术框架框架中的侵略性手术切除与治疗意图的造型框架可以导致镜像非IBC率的LRR速率。

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  • 来源
    《Annals of surgical oncology》 |2017年第10期|共8页
  • 作者

    Kelly J. Rosso; Audree B. Tadros; Anna Weiss; Carla L. Warneke; Sarah DeSnyder; Henry Kuerer; Naoto T. Ueno; Shane R. Stecklein; Wendy A. Woodward; Anthony Lucci;

  • 作者单位

    Department of Breast Surgical Oncology University of Texas MD Anderson Cancer Center;

    Department of Breast Surgical Oncology University of Texas MD Anderson Cancer Center;

    Department of Breast Surgical Oncology University of Texas MD Anderson Cancer Center;

    Department of Biostatics University of Texas MD Anderson Cancer Center;

    Department of Breast Surgical Oncology University of Texas MD Anderson Cancer Center;

    Department of Breast Surgical Oncology University of Texas MD Anderson Cancer Center;

    Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center;

    Department of Radiation Oncology University of Texas MD Anderson Cancer Center;

    Morgan Welch Inflammatory Breast Cancer Research Program and Clinic University of Texas MD;

    Department of Breast Surgical Oncology University of Texas MD Anderson Cancer Center;

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