...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Clinical and Experimental Pathology >Ductal plate in hepatoblasts in human fetal livers: I. ductal plate-like structures with cytokeratins 7 and 19 are occasionally seen within human fetal hepatoblasts
【24h】

Ductal plate in hepatoblasts in human fetal livers: I. ductal plate-like structures with cytokeratins 7 and 19 are occasionally seen within human fetal hepatoblasts

机译：人胎肝成肝细胞中的导管板：I.人胎成肝细胞中偶尔见到具有细胞角蛋白7和19的导管板状结构

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The author has studied the organogenesis of human intrahepatic bile duct in fetal livers. The developmental studies of the liver have focused mainly on the development of intrahepatic bile ducts including the ductal plate (DP). The DP is a single or double layered structures composed of small cuboidal cells and located in the interface between the hepatoblasts and portal mesenchyme. Herein, the author discovered the DP within the parenchymal hepatocytes. The DP-like structures within the hepatoblasts were found in 17 human fetal livers out of the 32 human fetal livers. The gestational ages of the 17 fetal livers were as follows: 7, 8, 9, 10 (n=2), 11, 12, 13, 14 (n=2), 15, 16, 17, 18, 19, 21, and 23 weeks. The presence of intraparenchymal DP-like structures were mainly found in the fetus of early gestational ages. Morphologically, the DP-like structures within the hepatoblasts were composed of small cuboidal epithelial cells with normal chromatin patterns. The cytoplasm was scant and relatively basophilic. The nuclei were small and round, and had no nucleoli. These cells formed the DP-like structures. The DP-like structures frequently formed cords, tubules, and duplicating patterns. These DP-like structures were scattered and the remaining hepatoblasts are normal hepatoblasts. The density of these DP-structures was low (one or two per 5 low power fields), but varied from case to case and area to area in the same case. The overall appearances were very similar to the true DP. Comparative observations of HE and CK immunostaining were performed. The DP-like structures within the hepatoblasts were positive for biliary-type CK7 and CK19. They were also positive for CK8 and CK18 that are expressed in both hepatocyte and biliary lineages. The true DP was positive for biliary-type CK7 and CK19. They were also positive for CK8 and CK18. Thus, the intraparenchymal DP-like structures were the same as the true DP located in the interface. Thus, the author discovered the intraparenchymal DP in the human fetal livers. This discovery should be confirmed by other researchers. If it is true, many studies of the functions of these intraparenchymal DPs are need.
机译：作者研究了胎儿肝脏中人肝内胆管的器官发生。肝脏的发育研究主要集中在肝内胆管的发展，包括导管板（DP）。 DP是由小型立方形细胞组成的单层或双层结构，位于成肝细胞与门静脉间质之间的界面中。在此，作者发现了实质肝细胞内的DP。在32个人胎肝中的17个人胎肝中发现了成肝细胞内的DP样结构。 17个胎儿肝脏的胎龄如下：7、8、9、10（n = 2），11、12、13、14（n = 2），15、16、17、18、19、21，和23周。实质内DP样结构的存在主要存在于胎龄较轻的胎儿中。从形态上讲，成肝细胞内的DP样结构由具有正常染色质模式的小立方形上皮细胞组成。细胞质很少且相对嗜碱性。细胞核小而圆形，没有核仁。这些细胞形成DP样结构。 DP状结构经常形成帘线，细管和重复图案。这些DP样结构散落，其余的成肝细胞为正常的成肝细胞。这些DP结构的密度很低（每5个低功率场1或2个），但在不同情况下以及同一情况下，每个区域的面积都不同。整体外观与真正的DP非常相似。进行HE和CK免疫染色的比较观察。肝母细胞中的DP样结构对胆汁型CK7和CK19呈阳性。他们还对在肝细胞和胆道谱系中表达的CK8和CK18呈阳性。胆汁型CK7和CK19的真正DP为阳性。他们也对CK8和CK18阳性。因此，实质内DP样结构与位于界面中的真实DP相同。因此，作者发现了人类胎儿肝脏中的实质内DP。这一发现应得到其他研究者的证实。如果属实，则需要对这些实质性体内DP的功能进行许多研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号