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首页> 外文会议>Annual and International Meeting of the Japanese Association for Animal Cell Technology >Purification of Hepatoblasts from Fetal Mouse Livers by Using a Temperature-Reversible Gelation Polymer and Their Application in Regenerative Medicine: Purification of Hepatoblasts and Their Applicati
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Purification of Hepatoblasts from Fetal Mouse Livers by Using a Temperature-Reversible Gelation Polymer and Their Application in Regenerative Medicine: Purification of Hepatoblasts and Their Applicati

机译：通过使用温度可逆凝胶化聚合物纯化胎儿小鼠肝细胞的纯化及其在再生医学中的应用：纯化肝细胞及其应用

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摘要

Hepatoblasts are liver progenitor cells generating both mature hepatocytes and biliary epithelial cells during fetal development, dependent on their positions placed in the liver (Fig. 1). They also have a remarkable growth potential during liver development . The use of hepatoblasts and adult hapatocytes as cell sources in hybrid-type artificial liver models may allow to maintain their hepatic functions for longer periods, in which dying mature hepatocytes could be replaced by hepatocytes differentiated from hepatoblasts. Hepatoblasts can also be useful for cell transplantation therapy in regenerative medicine.
机译：肝细胞是在胎儿发育过程中产生成熟肝细胞和胆道上皮细胞的肝祖细胞，依赖于其放置在肝脏中的位置（图1）。它们在肝脏发育过程中也具有显着的增长潜力。使用肝细胞和成人Hapatocytes作为杂化人工肝脏模型中的细胞来源可以允许维持其肝功能的较长时间，其中染色成熟肝细胞可以被肝细胞分化的肝细胞代替。肝细胞也可用于再生医学中的细胞移植治疗。

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