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首页> 外文期刊>International Journal of Clinical and Experimental Pathology >GRP78 overexpression as an unfavorable outcome in glioma patients
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GRP78 overexpression as an unfavorable outcome in glioma patients

机译：GRP78过表达是神经胶质瘤患者的不良预后

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Aims: In this study, the GRP78 expression and the correlation between GRP78 expression and clinicopathologic data in patients with glioma, including survival, were examined. Methods and results: The mRNA and protein levels of GRP78were respectively determined by real-time PCR and immunohistochemical analysis in 30 fresh glioma samples and 19 fresh normal brain samples as well as 156 paraffin-embedded glioma samples and 35 normal paraffin-embedded brain samples. The data showed that GRP78 mRNA is markedly upregulated compared with normal brain tissues. Consistent with this data, the GRP78 protein level was also significantly increased in glioma tissues compared with normal brain tissues. We further observed that high GRP78 protein expression was significantly associated with clinical stage (P = 0.0013) but did not correlate with age and gender. High, rather than low, GRP78 protein expression was associated with pooroverall survival rates (P = 0.001). Multivariate analysis indicated that high GRP78 protein expression was an independent prognostic indicator of patient survival (P = 0.002). Conclusions: Our findings demonstrate that GRP78 is overexpressed and plays a significant role in disease progression and poor outcome in patients with glioma.
机译：目的：在这项研究中，研究了神经胶质瘤患者的GRP78表达及其与临床病理数据之间的相关性，包括生存率。方法和结果：分别通过实时PCR和免疫组化分析，分别在30份新鲜的脑胶质瘤样品和19份新鲜的正常脑样品以及156份石蜡包埋的脑胶质瘤样品和35份正常石蜡包埋的脑样品中通过实时PCR和免疫组化分析测定了GRP78的mRNA和蛋白质水平。数据显示，与正常脑组织相比，GRP78 mRNA明显上调。与该数据一致，与正常脑组织相比，神经胶质瘤组织中的GRP78蛋白水平也显着增加。我们进一步观察到高GRP78蛋白表达与临床分期显着相关（P = 0.0013），但与年龄和性别无关。高而不是低的GRP78蛋白表达与总体存活率差有关（P = 0.001）。多变量分析表明，高GRP78蛋白表达是患者生存的独立预后指标（P = 0.002）。结论：我们的发现表明，GRP78过度表达，在神经胶质瘤患者的疾病进展和不良预后中起重要作用。

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