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CD-163 correlated with symptoms (pain or discomfort) of prostatic inflammation

机译：CD-163与前列腺炎症状（疼痛或不适）相关

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The purpose of this study is to identify significant immune-system related for symptom of patients with prostatic inflammation in order to investigate the etiology of prostatic inflammation which may relate to potentially chronic prostatitis (CP). We investigated the expression of immune system-related biomarkers such as Interleukin (IL) -6 (humoral immunity), CD-3 (T-lymphocyte), and CD-163 (macrophage) in prostate biopsy (PBx) specimens from patients with prostatic inflammation (without cancer) which had been neither clinically diagnosed benign prostatic hyperplasia nor chronic prostatitis. We examined the correlation between these markers’ expressions and the symptom scores using the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), International Prostate Symptom Score (IPSS)/quality of life (QOL) which are the index for lower urinary tract symptoms (LUTS). Our results showed CD-163 (macrophage) reflected pain or discomfort on NIH-CPSI scores (P = 0.0389 and r = 0.3307) in the patients with prostatic inflammation; however, the control patients had no significant correlation between symptom scores and those immune-related markers’ expression. These results suggest that pain or discomfort related to macrophages in the relationship between immune-system and the symptom of prostatic inflammation. In conclusion, CD-163, related to immune-system (macrophage), correlated with symptoms (pain or discomfort) of prostatic inflammation and might represent a significant immune-system related biomarker for pain or LUTS score in potentially CP.
机译：本研究的目的是鉴定与前列腺炎患者症状相关的重要免疫系统，以研究可能与潜在的慢性前列腺炎（CP）有关的前列腺炎的病因。我们研究了来自前列腺患者的前列腺活检（PBx）标本中与免疫系统相关的生物标志物的表达，例如白介素（IL）-6（体液免疫），CD-3（T淋巴细胞）和CD-163（巨噬细胞）既没有在临床上被诊断为良性前列腺增生也不是慢性前列腺炎的炎症（无癌症）。我们使用美国国立卫生研究院-慢性前列腺炎症状指数（NIH-CPSI），国际前列腺症状分数（IPSS）/生活质量（QOL）检查了这些标志物的表达与症状评分之间的相关性，这些指标是较低的指标尿路症状（LUTS）。我们的结果显示，前列腺炎患者CD-163（巨噬细胞）反映了NIH-CPSI评分的疼痛或不适（P = 0.0389和r = 0.3307）。但是，对照组患者的症状评分与那些免疫相关标志物的表达之间没有显着相关性。这些结果表明，在免疫系统与前列腺炎症状之间的关系中，与巨噬细胞有关的疼痛或不适。总之，与免疫系统（巨噬细胞）相关的CD-163与前列腺炎症状（疼痛或不适）相关，并且可能代表潜在的CP中与疼痛或LUTS评分相关的重要的免疫系统生物标记。

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