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首页> 外文期刊>International Journal of Clinical and Experimental Pathology >High expression of flotillin-2 is associated with poor clinical survival in cervical carcinoma
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High expression of flotillin-2 is associated with poor clinical survival in cervical carcinoma

机译：flotillin-2的高表达与宫颈癌的临床生存期差有关

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Aims: To investigate the expression and clinical significance of flotillin-2 (FLOT2) in cervical cancer (CC). Methods: We examined FLOT2 mRNA levels in 10 pairs of cervical cancer and adjacent normal tissues. Immunohistochemistry was performed to analyze FLOT2 protein expression in 115 archived cervical cancer samples. The association between FLOT2 levels, clinicopathologic factors and prognosis was analyzed statistically as well. Results: The cancer tissues of CC patients had clearly increased expression of FLOT2 at mRNA level as compared to adjacent nontumorous tissues. Survival analysis of CC patients indicated that FLOT2 expression was significantly associated with poor overall and local recurrence-free survival (P = 0.025 and P = 0.028, respectively). Moreover, FLOT2 expression was significantly correlated with clinical stage, tumor differentiation, and lymph nodes metastasis. Multivariate analysis revealed that FLOT2 expression was an independent prognostic factor for overall survival in CC patients. Conclusion: FLOT2 may serve as an oncogene in the development of CC, and may serve as a clinicopathologic biomarker for prognosis in CC patients.
机译：目的：探讨flotilin-2（FLOT2）在宫颈癌（CC）中的表达及其临床意义。方法：我们检查了10对子宫颈癌和邻近正常组织中FLOT2 mRNA的水平。进行了免疫组织化学分析，以分析115例已存档宫颈癌样品中的FLOT2蛋白表达。还对FLOT2水平，临床病理因素与预后之间的关联进行了统计分析。结果：与邻近的非肿瘤组织相比，CC患者的癌组织在mRNA水平上明显增加了FLOT2的表达。 CC患者的生存分析表明FLOT2表达与总体和局部无复发生存率显着相关（分别为P = 0.025和P = 0.028）。此外，FLOT2表达与临床分期，肿瘤分化和淋巴结转移密切相关。多变量分析显示，FLOT2表达是CC患者总体生存的独立预后因素。结论：FLOT2可能是CC发展的致癌基因，并可能成为CC患者预后的临床病理生物标志物。

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