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A four actin-binding protein signature model for poor prognosis of patients with esophageal squamous cell carcinoma

机译：食管鳞状细胞癌患者预后不良的四种肌动蛋白结合蛋白签名模型

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The actin cytoskeleton is a dynamic structure with actin-binding proteins (ABPs) playing an essential role in the regulation of migration, differentiation and signal transduction in all eukaryotic cells. We examined the relationship between altered expression of four ABPs and clinical parameters in esophageal squamous cell carcinoma (ESCC). To this end, we analyzed 152 formalin-fixed and paraffin-embedded esophageal curative resection specimens by immunohistochemistry for tensin, profilin-1, villin-1 and talin. A molecular predictor model, based on the combined expression of the four proteins, was developed to correlate the expression pattern of the four ABPs with clinical factors and prognosis of ESCC. According to the results, weak significance was found for tensin in lymph node metastasis (P=0.033), and profilin-1 in pTNM stage (P=0.031). However, our four-protein model showed strong correlation with the 5-year overall survival rate (P=0.002). Similarly, Kendall’s tau-b test also showed the relationship between the collective expression pattern of the four ABPs with lymph node metastasis (P=0.005) and pTNM stage (P=0.001). Our results demonstrate that the collective protein expression pattern of four actin-binding proteins could be a biomarker to estimate the prognosis of ESCC patients.
机译：肌动蛋白细胞骨架是一种动态结构，肌动蛋白结合蛋白（ABP）在所有真核细胞的迁移，分化和信号转导的调节中起着至关重要的作用。我们检查了食管鳞状细胞癌（ESCC）中四种ABP表达的改变与临床参数之间的关系。为此，我们通过免疫组化分析了152个福尔马林固定和石蜡包埋的食管根治性切除标本中的tensin，profilin-1，villin-1和talin。建立了一种基于四种蛋白质联合表达的分子预测模型，以将四种ABP的表达模式与临床因素和ESCC的预后相关联。根据这些结果，发现淋巴结转移中的肌腱蛋白（P = 0.033）和pTNM阶段的profilin-1（P = 0.031）的意义较弱。但是，我们的四蛋白模型显示出与5年总生存率的强相关性（P = 0.002）。同样，Kendall的tau-b测试也显示了四种ABP的集体表达模式与淋巴结转移（P = 0.005）和pTNM分期（P = 0.001）之间的关系。我们的结果表明，四种肌动蛋白结合蛋白的集体蛋白表达模式可能是评估ESCC患者预后的生物标记。

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