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首页> 外文期刊>International Journal of Clinical and Experimental Medicine >A retrospective comparative study of clinicopathological features between young and elderly women with breast cancer
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A retrospective comparative study of clinicopathological features between young and elderly women with breast cancer

机译：青年男女老年乳腺癌临床病理特征的回顾性比较研究

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Objective: This is a retrospective study to compare the clinicopathological features between young and elderly women with breast cancer. Methods: Totally 181 young and 186 elderly breast cancer patients were analyzed and compared in respects of the histological subtype, tumor number and size, tumor location, histological grading, UICC-pTNM pathological staging, and lymph node metastasis status. Results: Our results showed that invasive ductal carcinoma was the most frequent histotype in young and elderly breast cancer patients. The second most frequent histological subtype was intraductal carcinoma in the young group, while the second leading histotype was invasive lobular carcinoma in the elderly group. No significant differences in tumor number and location were observed between the young and elderly groups. The percentage of patients with tumor size T3 (diameter > 5 cm) and the proportion of patients with histological grade III in the young group were significantly higher than the elderly group. For UICC-pTNM pathological staging, patients at stages 0-I and II in the young group were less than, while patients at stage III was more than, in the elderly group. In addition, the axillary lymph node metastasis rate and the numbers of axillary lymph node metastasis were elevated in the young group, compared with the elderly group. Conclusion: Breast cancer in young female patients is associated with increased aggressiveness and potential malignancy. Our findings might contribute to future diagnosis and treatment of breast cancer in young women.
机译：目的：这是一项回顾性研究，比较年轻和老年妇女乳腺癌的临床病理特征。方法：对181例年轻乳腺癌患者和186例老年乳腺癌患者进行了组织学亚型，肿瘤数目和大小，肿瘤位置，组织学分级，UICC-pTNM病理分期和淋巴结转移状态的分析和比较。结果：我们的结果表明，浸润性导管癌是年轻和老年乳腺癌患者中最常见的组织型。在青年组中，第二常见的组织学亚型是导管内癌，而在老年组中，第二主要的组织学类型是浸润性小叶癌。青年组和老年组之间在肿瘤数量和位置上均无显着差异。青年组中肿瘤大小为T3（直径为5厘米）的患者百分比和组织学分级为III级的患者比例显着高于老年人组。对于UICC-pTNM病理分期，年轻组的0-I和II期患者少于老年组，而III期的患者高于老年组。此外，与老年组相比，青年组的腋窝淋巴结转移率和腋窝淋巴结转移数均升高。结论：年轻女性患者的乳腺癌与侵略性增加和潜在的恶性肿瘤有关。我们的发现可能有助于将来年轻女性乳腺癌的诊断和治疗。

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