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首页> 外文期刊>International Journal of Electrochemical Science >Carbon Nanotubes Modified and Conventional Selective Electrodes for Determination of Selegiline Hydrochloride and Its Pharmaceutical Preparations
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Carbon Nanotubes Modified and Conventional Selective Electrodes for Determination of Selegiline Hydrochloride and Its Pharmaceutical Preparations

机译：碳纳米管修饰的常规选择电极测定盐酸司来吉兰及其药物制剂

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摘要

The construction and performance characteristics of selegiline (Sel) carbon paste (CPEs) and plasticmembranes electrodes are described. The cited electrodes are based on the ion associates selegilinephosphomolybdate (Sel-PMA) or phosphotungstate (Sel-PTA). Matrix composition of each electrodeis optimized on the basis of effects of type and concentration of the ionophore as well as influence ofthe selected plasticizers. Carbon nanotubes (CNTs) have a good conductivity which helps thetransduction of the signal in carbon paste electrode, so the addition small quantity of multi-wall carbonnanotubes (MWCNTs) particles to the composition of carbon paste electrode gave a betterperformance characteristics for Sel-electrodes with Nernstion slope of 59.50 and 58.20 mV at 25 for Sel-PMA and Sel-PTA ion associates, respectively within a linear concentration range from 1.0x10 to 1.0x10 M for MWCNTs modified paste electrodes. The mean recovery of the amounts taken ofpure and pharmaceutical preparations ranged from 95.2 to 103.5% with RSD = 0.2.8%. While forurine and plasma samples, the recovery values ranged from 96.2 to 103.5% with RSD =0.2-0.7%, withlimit of detection (LOD), ranged from 1.52 to 21.26 g/L, while the limit of quantification (LOQ)ranged from 1.52 to 20.36 g/L for the studied electrodes.
机译：描述了司来吉兰（Sel）碳糊（CPE）和塑料膜电极的结构和性能特征。引用的电极基于离子缔合硒基硒代磷酸钼（Sel-PMA）或磷钨酸盐（Sel-PTA）。根据离子载体的类型和浓度以及所选增塑剂的影响，优化每个电极的基质组成。碳纳米管（CNTs）具有良好的导电性，有助于碳糊电极中信号的传导，因此，向碳糊电极中添加少量的多壁碳纳米管（MWCNTs）颗粒可为Sel电极提供更好的性能。对于Sel-PMA和Sel-PTA离子缔合剂，在25时的能级斜率分别为59.50和58.20 mV，对于MWCNTs修饰的糊状电极，其线性浓度范围分别为1.0x10至1.0x10M。纯制剂和药物制剂的平均回收量为95.2至103.5％，RSD = 0.2.8％。对于鸟嘌呤和血浆样品，回收率范围为96.2至103.5％，RSD = 0.2-0.7％，检出限（LOD）为1.52至21.26 g / L，而定量限（LOQ）为1.52到20.36 g / L的电极。

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