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首页> 外文期刊>International Journal of Electrochemical Science >Synthesis and Electrochemistry Evaluation of Multivalent o- Aminobenzamides and Quinazoline-2,4-diones.
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Synthesis and Electrochemistry Evaluation of Multivalent o- Aminobenzamides and Quinazoline-2,4-diones.

机译：多价邻氨基苯甲酰胺和喹唑啉-2,4-二酮的合成和电化学评估。

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摘要

The o-aminobenzamides (OAB) and quinazoline-2,4-diones (QZD) are alkaloids with important biological properties such as sedatives, antipsychotics and anticonvulsants, these last properties can be evaluated by electrochemistry methods, using its electron transfer capacity. In this study six compounds (OAB, QZD) were synthesized and characterized, using spacers groups to link the functional moieties (presents on the mono, di and tri substituted systems of each alkaloid kind), when the spacers groups are present, an increase of pharmacological properties has been shown. We carried on electrochemistry evaluations to the synthetized compounds to predict the electron transfer. The results show a single oxidation potential (OP) for the mono and di-substituted compounds (OAB, QZD), and two different OP when the system is trimeric (OAB, QZD). The intensity of the OP signals in the open systems (OAB) is considerable higher in comparison with the closed systems (QZD), these oxidation potentials are assignation at amine groups, and the tertiary amines of trimeric compound present the highest intensity oxidation signals in comparison with secondary amines. The most favorable compound to realize the electron transfer are the open trimeric system.
机译：邻氨基苯甲酰胺（OAB）和喹唑啉-2,4-二酮（QZD）是具有重要生物学特性的生物碱，例如镇静剂，抗精神病药和抗惊厥药，这些最后的特性可以通过电化学方法使用其电子转移能力进行评估。在这项研究中，合成并表征了六种化合物（OAB，QZD），使用间隔基团连接功能部分（存在于每种生物碱类型的单，双和三取代系统上），如果存在间隔基，则增加已经显示出药理特性。我们对合成的化合物进行了电化学评估，以预测电子转移。结果显示单和双取代化合物（OAB，QZD）的单氧化电位（OP），而当系统为三聚体（OAB，QZD）时显示两个不同的OP。与封闭系统（QZD）相比，开放系统（OAB）中OP信号的强度要高得多，这些氧化电位是在胺基上分配的，而三聚体化合物的叔胺则是强度最高的氧化信号。与仲胺。实现电子转移的最有利化合物是开放三聚体系统。

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