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首页> 外文期刊>International Journal of Electrochemical Science >Zinc Oxide Nanoflowers Based Graphene Nanocomposite Platform for Catalytic Studies of Febuxostat
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Zinc Oxide Nanoflowers Based Graphene Nanocomposite Platform for Catalytic Studies of Febuxostat

机译：基于氧化锌纳米花的石墨烯纳米复合材料平台的非布索坦催化研究

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摘要

A novel graphene/zinc nanoflowers nano-composite modified glassy carbon electrode(GR/ZnOnFs/GCE) based electrochemical transducer system has been developed for the sensitivevoltammetric analysis of a muscle relaxant drug febuxostat (FEB) in methyl alcohol at pH 6.5 BrittonRobinson (BR) buffer. The developed GR/ZnOnFs/GCE) sensor was characterized by microscopic,spectroscopic and electrochemical techniques to get significant information about the morphology,composition and sensing performance of the developed electrode towards reduction of FEB. Variouskinetic parameters affecting the monitored electrocatalytic response were evaluated. SWV studies-1 shows linear response between increasing concentrations of FEB (10-400 ng mL ) and cathodic2 current with correlation coefficient (r ) of 0.9954 with reproducibility of 3.26%. The sensing utility ofproposed sensor was extended to in vitro determination of the drug in pharmaceutical formulation andin waste water with an acceptable recovery and reproducibility. The fabricated (GR/ZnOnFs/GCE)sensor holds great promise for simple and sensitive quantification of febuxostat using electroanalyticaltechniques.
机译：基于石墨烯/锌纳米花纳米复合修饰玻碳电极（GR / ZnOnFs / GCE）的电化学换能器系统已经开发出来，用于pH 6.5的甲醇中肌肉松弛药物非布司他（FEB）的灵敏伏安分析。BrittonRobinson（BR）缓冲。通过显微，光谱和电化学技术对已开发的GR / ZnOnFs / GCE）传感器进行了表征，以获取有关已开发电极对减少FEB的形态，组成和传感性能的重要信息。评价影响所监测的电催化反应的各种动力学参数。 SWV研究-1显示，FEB（10-400 ng mL）的浓度增加与阴极电流之间的线性响应，相关系数（r）为0.9954，可重复性为3.26％。拟议的传感器的传感实用性已扩展到体外测定药物制剂和废水中的药物，并具有可接受的回收率和重现性。制成的（GR / ZnOnFs / GCE）传感器具有使用电分析技术对非布索坦进行简单而灵敏的定量分析的巨大前景。

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