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首页> 外文期刊>International Journal of Experimental Diabetes Research: Experimental Diabesity Research >Maternal Manganese Restriction Increases Susceptibility to High-Fat Diet-Induced Dyslipidemia and Altered Adipose Function in WNIN Male Rat Offspring
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Maternal Manganese Restriction Increases Susceptibility to High-Fat Diet-Induced Dyslipidemia and Altered Adipose Function in WNIN Male Rat Offspring

机译：母体锰限制增加WNIN雄性大鼠后代对高脂饮食诱发的血脂异常和脂肪功能改变的敏感性

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摘要

Growth in utero is largely a reflection of nutrient and oxygen supply to the foetus. We studied the effects of Mn restriction per se, maternal Mn restriction, and postnatal high-fat feeding in modulating body composition, lipid metabolism and adipocyte function in Wistar/NIN (WNIN) rat offspring. Female weanling, WNIN rats received ad libitum for 4 months, a control or Mn-restricted diet and were mated with control males. Some restricted mothers were rehabilitated with control diet from conception (MnRC) or parturition (MnRP), and their offspring were raised on control diet. Some restricted offspring were weaned onto control diet (MnRW), while others continued on restricted diet throughout (MnR). A set of offspring from each group was fed high-fat diet from 9 months onwards. Body composition, adipocytes function, and lipid metabolism were monitored in male rat offspring at regular intervals. Maternal manganese restriction increased the susceptibility of the offspring to high-fat-induced adiposity, dyslipidaemia, and a proinflammatory state but did not affect their glycemic or insulin status.
机译：子宫内的生长在很大程度上反映了胎儿的营养和氧气供应。我们研究了锰限制本身，母体锰限制和产后高脂喂养对调节Wistar / NIN（WNIN）大鼠后代的身体组成，脂质代谢和脂肪细胞功能的影响。雌性断奶的WNIN大鼠自由进食4个月，接受对照或锰限制饮食，并与对照雄性交配。一些受限制的母亲通过受孕（MnRC）或分娩（MnRP）的对照饮食进行了康复，其后代通过对照饮食饲养。一些限制性后代断奶后加入对照饮食（MnRW），而另一些则继续采用限制性饮食（MnR）。从9个月起，每组的一组后代都接受高脂饮食。定期监测雄性大鼠后代的身体成分，脂肪细胞功能和脂质代谢。母体对锰的限制增加了后代对高脂诱导的肥胖，血脂异常和促炎状态的敏感性，但并未影响其血糖或胰岛素状态。

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