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首页> 外文期刊>International Journal of Experimental Diabetes Research: Experimental Diabesity Research >Choroidal Thickness and Ganglion Cell Complex in Pubescent Children with Type 1 Diabetes without Diabetic Retinopathy Analyzed by Spectral Domain Optical Coherence Tomography
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Choroidal Thickness and Ganglion Cell Complex in Pubescent Children with Type 1 Diabetes without Diabetic Retinopathy Analyzed by Spectral Domain Optical Coherence Tomography

机译：光谱域光学相干层析成像技术分析未患糖尿病视网膜病变的1型糖尿病青春期儿童的脉络膜厚度和神经节细胞复合物

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Aim. To assess the retinal and choroidal thickness and ganglion cell complex (GCC) in pubescent children with type 1 diabetes (T1D) without diabetic retinopathy (DR), using spectral domain optical coherence tomography (SD-OCT). Materials and Method. Sixty-four right eyes of 64 subjects with T1D and 45 right eyes of 45 age-matched healthy volunteers (control group) were enrolled in this study. The mean age of the subjects and controls was 15.3 (±SD?=?2.2) and 14.6 (±SD?=?1.5), respectively. SD-OCT was performed using RTVue XR Avanti. Ganglion cell complex (GCC), GCC focal loss volume (FLV), GCC global loss volume (GLV), choroidal thickness (CT), foveal (FT) and parafoveal thickness (PFT), and foveal (FV) and parafoveal volume (PFV) data were analyzed. Results. There was no significant difference between subjects and controls in the CT in the fovea and nasal, temporal, superior, and inferior quadrants of the macula. There were no significant correlations between CT, duration of diabetes, and HbA1C level ( and , resp.). GCC thickness did not differ significantly between the groups (), but there was a significant difference in FLV (). Significant differences between the groups were found in the PFT and PFV ( and , resp.). There was a significant negative correlation between PFT, PFV, and HbA1C level ( and , resp.). Conclusions. Choroidal thickness remains unchanged in children with T1D. Increased GCC FLV might suggest an early alteration in neuroretinal tissue. Parafoveal retinal thickness is decreased in pubescent T1D children and correlates with HbA1C level. OCT can be considered a part of noninvasive screening in children with T1D and a tool for early detection of retinal and choroidal abnormalities. Further OCT follow-up is needed to determine whether any of the discussed OCT measurements are predictive of future DR severity.
机译：目标。使用光谱域光学相干断层扫描（SD-OCT）评估未患有糖尿病性视网膜病变（DR）的1型糖尿病（T1D）青春期儿童的视网膜和脉络膜厚度以及神经节细胞复合物（GCC）。材料和方法。本研究纳入了64位患有T1D的受试者的64只右眼和45位年龄相匹配的健康志愿者（对照组）的45只右眼。受试者和对照的平均年龄分别为15.3（±SD≤2.2）和14.6（±SD≤1.5）。使用RTVue XR Avanti执行SD-OCT。神经节细胞复合物（GCC），GCC局灶损失量（FLV），GCC整体损失量（GLV），脉络膜厚度（CT），中央凹（FT）和中央凹厚度（PFT），中央凹（FV）和中央凹体积（PFV） ）的数据进行了分析。结果。中央凹CT和黄斑鼻，颞，上，下象限的CT受试者与对照之间无显着差异。 CT，糖尿病病程和HbA1C水平之间无显着相关性（和，分别）。两组之间的GCC厚度没有显着差异（），但FLV（）有显着差异。在PFT和PFV中发现了两组之间的显着差异（和分别）。 PFT，PFV和HbA1C水平之间存在显着的负相关（和，分别）。结论。 T1D患儿的脉络膜厚度保持不变。 GCC FLV升高可能提示神经视网膜组织发生早期改变。青春期T1D患儿的视网膜中央凹视网膜厚度减少，并与HbA1C水平相关。 OCT可被认为是T1D儿童无创筛查的一部分，也是早期检测视网膜和脉络膜异常的工具。需要进一步的OCT随访以确定任何讨论的OCT测量是否可以预测未来的DR严重程度。

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