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首页> 外文期刊>International Journal of Environmental Research and Public Health >The Influence of Quercetin on Maternal Immunity, Oxidative Stress, and Inflammation in Mice with Exposure of Fine Particulate Matter during Gestation
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The Influence of Quercetin on Maternal Immunity, Oxidative Stress, and Inflammation in Mice with Exposure of Fine Particulate Matter during Gestation

机译：槲皮素对妊娠期细颗粒物暴露的小鼠免疫力，氧化应激和炎症的影响

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The objective is to investigate the influence of PM 2.5 exposure on peripheral blood lymphocyte subsets in pregnant mice and the antagonism of quercetin on adverse effects induced by PM 2.5 exposure. Pregnant mice were randomly divided into control group, PM 2.5 model group and 3 quercetin intervention groups. Dams in all groups except the control group were exposed to PM 2.5 suspension by intratracheal instillation on gestational day (GD) 3, 6, 9, 12 and 15. Meanwhile, each dam was given 0.15% carboxymethylcellulose sodium (CMCS) (control group & PM 2.5 model group) and different doses of quercetin (quercetin intervention groups) by gavage once a day from GD0 to GD17. The percentage of lymphocyte subsets, Biomarkers of systemic inflammation injuries (IL-2, IL-6, IL-8 & TNF-α) and oxidative stress indicators (CAT, GSH & HO-1) in peripheral blood of the dams were analyzed. The number of T cells increased, accompanied by increased level of IL-2, IL-6, IL-8 and HO-1 due to PM 2.5 exposure. Less CD4+ and CD8+ T cells were counted in 100 mg/kg quercetin intervention group, compared with PM 2.5 model group. Quercetin may inhibit cytokine production, especially in IL-6 and IL-8 and may upgrade the level of HO-1. Our findings indicate that PM 2.5 could significantly influence the distribution of T-lymphocyte subsets, activate inflammatory reaction and elevate oxidative stress level in peripheral blood of pregnant mice. Certain dose of quercetin administration during pregnancy may protect the dams against the adverse effects through various ways.
机译：目的是研究暴露PM 2.5对怀孕小鼠外周血淋巴细胞亚群的影响，以及槲皮素对PM 2.5暴露引起的不良反应的拮抗作用。将妊娠小鼠随机分为对照组，PM 2.5模型组和3个槲皮素干预组。除对照组外，其余各组在妊娠第3、6、9、12和15日通过气管内滴注暴露于PM 2.5悬浮液中。同时，给每只大坝分别添加0.15％的羧甲基纤维素钠（CMCS）（对照组和对照组）。 PM 2.5模型组）和每天一次从GD0至GD17灌胃不同剂量的槲皮素（槲皮素干预组）。分析了大坝外周血淋巴细胞亚群的百分比，系统性炎症损伤的生物标志物（IL-2，IL-6，IL-8和TNF-α）以及氧化应激指标（CAT，GSH和HO-1）。由于暴露于PM 2.5，T细胞数量增加，同时伴随着IL-2，IL-6，IL-8和HO-1水平的升高。槲皮素干预组100 mg / kg的CD4 +和CD8 + T细胞计数低于PM 2.5模型组。槲皮素可能会抑制细胞因子的产生，尤其是在IL-6和IL-8中，并且可能会提高HO-1的水平。我们的研究结果表明，PM 2.5可以显着影响妊娠小鼠外周血T淋巴细胞亚群的分布，激活炎症反应并提高氧化应激水平。在怀孕期间服用一定剂量的槲皮素可以通过多种方式保护水坝免受不良影响。

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