...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Environmental Research and Public Health >Pomegranate ( Punica granatum ) Juice Shows Antioxidant Activity against Cutaneous Leishmaniasis-Induced Oxidative Stress in Female BALB/c Mice
【24h】

Pomegranate ( Punica granatum ) Juice Shows Antioxidant Activity against Cutaneous Leishmaniasis-Induced Oxidative Stress in Female BALB/c Mice

机译：石榴汁（Punica granatum）对雌性BALB / c小鼠皮肤性利什曼病引起的氧化应激具有抗氧化活性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Leishmania species are parasites that multiply within phagocytes and cause several clinical diseases characterized by single or multiple ulcerations. One of the complications that can induce tissue damage and the resulting scars is caused by secondary bacterial infections. Studies to find new, effective, and safe oral drugs for treating leishmaniasis are being conducted since several decades, owing to the problems associated with the use of antimonials available. Previously, the antiparasitic and antioxidant properties of Punica granatum (pomegranate, P. granatum ) have been reported. Therefore, in the present study, we aimed to investigate the antileishmanial activity of pomegranate aqueous juice in vitro and in female BALB/c mice. A 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in Leishmania major promastigotes and alterations in the antioxidant status, liver function, and skin histological changes in L. major -infected mice orally treated with pomegranate juice alone and in combination with the antibiotic ciprofloxacin, were used to investigate the in vitro and in vivo antileishmanial activity of pomegranate juice, respectively. Oral P. granatum juice treatment significantly reduced the average size of cutaneous leishmaniasis lesions compared with that of the untreated mice. This antileishmanial activity of P. granatum was associated with enhanced antioxidant enzyme activities. Histopathological evaluation proved the antileishmanial activity of P. granatum , but did not reveal changes in the treated animals, compared to the positive control. In conclusion, P. granatum shows high and fast antileishmanial activity probably by boosting the endogenous antioxidant activity.
机译：利什曼原虫是在吞噬细胞内繁殖并引起以单溃疡或多溃疡为特征的几种临床疾病的寄生虫。继发性细菌感染可导致组织损伤并导致疤痕，这是其中一种并发症。由于使用现有的抗生素存在的问题，几十年来一直在进行寻找新的，有效和安全的口服药物治疗利什曼病的研究。以前，已经报道了石榴（Punica granatum）（石榴，P。granatum）的抗寄生虫和抗氧化特性。因此，在本研究中，我们旨在研究石榴汁在体外和在雌性BALB / c小鼠中的抗胰酶活性。利什曼原虫主要前鞭毛体中3-（4.5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化物（MTT）测定以及口服经L.单独使用石榴汁或与抗生素环丙沙星联合使用分别研究石榴汁的体外和体内抗胰酶活性。与未治疗的小鼠相比，口服体育颗粒汁显着降低了皮肤利什曼病皮损的平均大小。颗粒假单胞菌的这种抗畜牧活性与增强的抗氧化酶活性有关。与阳性对照相比，组织病理学评估证明了颗粒状毕赤酵母的抗皱活性，但未显示出治疗动物的变化。总之，体育颗粒可能通过提高内源性抗氧化活性而显示出高而快速的抗牛鞭毛活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号