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首页> 外文期刊>International Journal of Environmental Research and Public Health >Hazardous Compounds in Tobacco Smoke
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Hazardous Compounds in Tobacco Smoke

机译：烟草烟雾中的有害化合物

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摘要

Tobacco smoke is a toxic and carcinogenic mixture of more than 5,000 chemicals. The present article provides a list of 98 hazardous smoke components, based on an extensive literature search for known smoke components and their human health inhalation risks. An electronic database of smoke components containing more than 2,200 entries was generated. Emission levels in mainstream smoke have been found for 542 of the components and a human inhalation risk value for 98 components. As components with potential carcinogenic, cardiovascular and respiratory effects have been included, the three major smoke-related causes of death are all covered by the list. Given that the currently used Hoffmann list of hazardous smoke components is based on data from the 1990s and only includes carcinogens, it is recommended that the current list of 98 hazardous components is used for regulatory purposes instead. To enable risk assessment of components not covered by this list, thresholds of toxicological concern (TTC) have been established from the inhalation risk values found: 0.0018 μg day−1 for all risks, and 1.2 μg day−1 for all risks excluding carcinogenicity, the latter being similar to previously reported inhalation TTCs.
机译：烟草烟雾是由五千多种化学物质构成的有毒致癌混合物。本文根据广泛的文献资料，提供了98种有害烟雾成分的清单，以查找已知的烟雾成分及其对人体健康的吸入风险。生成了包含2200多个条目的烟雾成分电子数据库。已发现542种成分的主流烟雾中的排放水平和98种成分的人体吸入风险值。由于已包括具有潜在致癌，心血管和呼吸作用的成分，该清单涵盖了三种与烟雾有关的主要死亡原因。鉴于当前使用的霍夫曼有害烟雾成分清单是基于1990年代的数据，并且仅包含致癌物，因此建议将当前的98种有害成分清单用于监管目的。为了能够对该列表未涵盖的成分进行风险评估，已从发现的吸入风险值中确定了毒理学关注阈值（TTC）：所有风险为0.0018μgday -1 ，1.2μgday < sup> -1 用于排除致癌性的所有风险，后者与先前报道的吸入TTC相似。

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