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首页> 外文期刊>International Journal of Environmental Research and Public Health >Influence of Occupational and Environmental Exposure to Low Concentrations of Polychlorobiphenyls and a Smoking Habit on the Urinary Excretion of Corticosteroid Hormones
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Influence of Occupational and Environmental Exposure to Low Concentrations of Polychlorobiphenyls and a Smoking Habit on the Urinary Excretion of Corticosteroid Hormones

机译：职业和环境暴露对低浓度的多氯联苯和吸烟习惯对皮质类固醇激素尿排泄的影响

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The effects of occupational exposure to low concentrations of polychlorobiphenyls (PCBs) on the urinary excretion of corticosteroid hormones were evaluated, taking into account the influence of cigarette smoking. The study included 26 males working as electrical maintenance staff in a steel factory, previously exposed to a mixture of PCBs (exposed workers), and 30 male workers with no occupational exposure to PCBs (controls). Serum PCBs (33 congeners), urinary 17-hydroxycorticosteroids, 17-ketosteroids (KS) and pregnanes, and their respective glucuronidated and sulfonated compounds, were determined for each subject. PCBs were significantly higher in the exposed workers than controls, and were correlated with age. Both the urinary concentrations of the total 17-KS and pregnanes, and those of some single steroids and their glucuronidated compounds, were significantly lower in the exposed workers than controls, but higher in smokers than the non-smokers + ex-smokers. Two-way analysis of variance showed a negative association between serum PCBs and both total glucuronidated 17-KS and total and glucuronidated pregnanes, and a positive association between cigarette smoking and both total and glucuronidated 17-KS. PCBs seem to act as endocrine disruptors by reducing the urinary excretion of corticosteroid hormones, particularly of the glucuronidated fraction. Cigarette smoking could boost these effects of PCBs in smokers.
机译：考虑到吸烟的影响，评估了职业性低浓度多氯联苯（PCBs）暴露对尿中皮质类固醇激素排泄的影响。这项研究包括26名男性在钢铁厂担任电气维护人员，这些男性以前曾接触过多氯联苯（暴露的工人），还有30名男性没有职业接触多氯联苯（对照）。为每个受试者确定了血清多氯联苯（33种同源物），尿液中的17-羟基皮质类固醇，17-酮类固醇（KS）和孕烷，以及它们各自的葡萄糖醛酸化和磺化化合物。暴露工人的PCBs明显高于对照组，并且与年龄有关。在暴露的工人中，总17-KS和孕烷的尿液浓度以及某些类固醇及其葡萄糖醛酸化化合物的尿液浓度均显着低于对照组，但吸烟者中的尿液浓度高于不吸烟者+前吸烟者。差异的双向分析显示，血清PCBs与总葡糖醛酸化的17-KS和总葡糖醛酸化的孕激素之间呈负相关，而吸烟与总葡糖醛酸化的17-KS和两者之间呈正相关。多氯联苯似乎通过减少皮质类固醇激素（尤其是葡萄糖醛酸化部分）的尿排泄而充当内分泌干扰物。吸烟可以增强吸烟者体内多氯联苯的这些作用。

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