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首页> 外文期刊>International Journal of Environmental Research and Public Health >Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis
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Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis

机译：LPP和TAGAP多态性与腹腔疾病风险的关联：荟萃分析

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Background: Lipoma preferred partner ( LPP ) and T-cell activation Rho GTPase activating protein ( TAGAP ) polymorphisms might influence the susceptibility to celiac disease. Therefore, we performed a meta-analysis by identifying relevant studies to estimate the risks of these polymorphisms on celiac disease. Methods: The PubMed, Web of Science and Embase databases were searched (up to October 2016) for LPP rs1464510 and TAGAP rs1738074 polymorphisms. Results: This meta-analysis included the same 7 studies for LPP rs1464510 and TAGAP rs1738074. The minor risk A allele at both rs1464510 and rs1738074 carried risks (odds ratios) of 1.26 (95% CI: 1.22–1.30) and 1.17 (95% CI: 1.14–1.21), respectively, which contributed to increased risks in all celiac disease patients by 10.72% and 6.59%, respectively. The estimated lambdas were 0.512 and 0.496, respectively, suggesting that a co-dominant model would be suitable for both gene effects. Conclusions: This meta-analysis provides robust estimates that polymorphisms in LPP and TAGAP genes are potential risk factors for celiac disease in European and American. Prospective studies and more genome-wide association studies (GWAS) are needed to confirm these findings, and some corresponding molecular biology experiments should be carried out to clarify the pathogenic mechanisms of celiac disease.
机译：背景：脂瘤首选伴侣（LPP）和T细胞活化Rho GTPase活化蛋白（TAGAP）多态性可能会影响乳糜泻的易感性。因此，我们通过鉴定相关研究来进行荟萃分析，以评估这些多态性对乳糜泻的风险。方法：截至2016年10月，在PubMed，Web of Science和Embase数据库中搜索LPP rs1464510和TAGAP rs1738074多态性。结果：这项荟萃分析包括针对LPP rs1464510和TAGAP rs1738074的相同7项研究。次要风险rs1464510和rs1738074的等位基因分别具有1.26（95％CI：1.22-1.30）和1.17（95％CI：1.14-1.21）的风险（比值），这导致所有乳糜泻的风险增加患者分别减少了10.72％和6.59％。估计的λ分别为0.512和0.496，这表明共同主导模型将同时适合两种基因效应。结论：这项荟萃分析提供了可靠的估计，即在欧洲和美洲，LPP和TAGAP基因的多态性是乳糜泻的潜在危险因素。需要前瞻性研究和更多的全基因组关联研究（GWAS）来证实这些发现，并且应该进行一些相应的分子生物学实验来阐明乳糜泻的致病机制。

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