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首页> 外文期刊>International Journal of Environmental Research and Public Health >FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes
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FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes

机译：2型糖尿病的FADS基因多态性，脂肪酸去饱和酶活性和HDL-C

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Polyunsaturated fatty acids (PUFA) correlate with risk of dyslipidemia and cardiovascular diseases. Fatty acid desaturase ( FADS ) single nucleotide polymorphisms (SNPs) modulate circulating PUFA concentrations. This study examined influence of FADS1 and FADS2 genetic variants on desaturase activities and blood lipid concentrations in type 2 diabetes patients, and further assessed their interrelationships. Selected SNPs ( FADS1 : rs174547, rs174548, rs174550; FADS2 : rs174575, rs174576, rs174583, rs498793 and rs2727270) were genotyped in 820 type 2 diabetes patients and compared with those reported in the HapMap. Patient subgroups ( n = 176) without taking lipid-lowering medicine were studied to assess influence of tag SNPs including rs174547, rs174575, rs498793 and rs2727270 on delta-5 desaturase (D5D: 20:4 (n-6)/20:3 (n-6)) and delta-6 desaturase (D6D:18:3 (n-6)/18:2 (n-6)) activities, and blood lipids. FADS1 rs174547 TT/TC/CC and FADS2 rs2727270 CC/CT/TT were significantly ( p for trend < 0.05) associated with reduced HDL-C, D5D and D6D activities. Upon adjustment for confounders, D5D ( p = 0.006) correlated significantly and D6D marginally ( p = 0.07) correlated with increased HDL-C levels, whereas rs174547 and rs2727270 polymorphisms were not associated. D6D andD5D activities may play a role in modulating HDL-C levels in type 2 diabetes. Future studies with larger sample sizes are needed to investigate how FADS genetic variations interact with desaturase activities or PUFAs in the metabolism of lipoproteins in diabetic patients.
机译：多不饱和脂肪酸（PUFA）与血脂异常和心血管疾病的风险相关。脂肪酸去饱和酶（FADS）单核苷酸多态性（SNP）调节循环PUFA浓度。这项研究检查了FADS1和FADS2基因变异对2型糖尿病患者去饱和酶活性和血脂浓度的影响，并进一步评估了它们之间的相互关系。在820位2型糖尿病患者中对选定的SNPs（FADS1：rs174547，rs174548，rs174550; FADS2：rs174575，rs174576，rs174583，rs498793和rs2727270）进行基因分型，并与HapMap中报道的那些进行比较。研究了未服用降脂药的患者亚组（n = 176）以评估包括rs174547，rs174575，rs498793和rs2727270在内的SNP标签对delta-5去饱和酶的影响（D5D：20：4（n-6）/ 20：3（ n-6））和delta-6去饱和酶（D6D：18：3（n-6）/ 18：2（n-6））活性和血脂。 FADS1 rs174547 TT / TC / CC和FADS2 rs2727270 CC / CT / TT与降低的HDL-C，D5D和D6D活性显着相关（趋势p <0.05）。在对混杂因素进行调整后，D5D（p = 0.006）与HDL-C水平升高显着相关，而D6D与HDL-C水平升高之间的相关性很小（p = 0.07），而rs174547和rs2727270的多态性则不相关。 D2D和D5D活动可能在2型糖尿病的HDL-C水平调节中发挥作用。需要进行更大样本量的未来研究，以研究FADS遗传变异如何与去饱和酶活性或PUFA在糖尿病患者脂蛋白代谢中相互作用。

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