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首页> 外文期刊>International Journal of Environmental Research and Public Health >Benzene Exposure Alters Expression of Enzymes Involved in Fatty Acid β-Oxidation in Male C3H/He Mice
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Benzene Exposure Alters Expression of Enzymes Involved in Fatty Acid β-Oxidation in Male C3H/He Mice

机译：苯暴露改变雄性C3H / He小鼠脂肪酸β-氧化酶的表达

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摘要

Benzene is a well-known hematotoxic carcinogen that can cause leukemia and a variety of blood disorders. Our previous study indicated that benzene disturbs levels of metabolites in the fatty acid β-oxidation (FAO) pathway, which is crucial for the maintenance and function of hematopoietic and leukemic cells. The present research aims to investigate the effects of benzene on changes in the expression of key enzymes in the FAO pathway in male C3H/He mice. Results showed that benzene exposure caused reduced peripheral white blood cell (WBC), red blood cell (RBC), platelet (Pit) counts, and hemoglobin (Hgb) concentration. Investigation of the effects of benzene on the expression of FA transport- and β-oxidation-related enzymes showed that expression of proteins Cpt1a, Crat, Acaa2, Aldh1l2, Acadvl, Crot, Echs1, and Hadha was significantly increased. The ATP levels and mitochondrial membrane potential decreased in mice exposed to benzene. Meanwhile, reactive oxygen species (ROS), hydrogen peroxide (H2O2), and malondialdehyde (MDA) levels were significantly increased in the benzene group. Our results indicate that benzene induces increased expression of FA transport and β-oxidation enzymes, mitochondrial dysfunction, and oxidative stress, which may play a role in benzene-induced hematotoxicity.
机译：苯是一种众所周知的血液毒性致癌物，可引起白血病和多种血液疾病。我们以前的研究表明，苯干扰脂肪酸β-氧化（FAO）途径中代谢物的水平，这对于维持造血细胞和白血病细胞的功能至关重要。本研究旨在调查苯对雄性C3H / He小鼠FAO途径中关键酶表达变化的影响。结果表明，苯暴露导致外周血白细胞（WBC），红细胞（RBC），血小板（Pit）计数和血红蛋白（Hgb）浓度降低。苯对FA转运和β-氧化相关酶表达的影响研究表明，蛋白Cpt1a，Crat，Acaa2，Aldh12，Acadvl，Crot，Echs1和Hadha的表达显着增加。暴露于苯的小鼠的ATP水平和线粒体膜电位降低。同时，苯基中的活性氧（ROS），过氧化氢（H2O2）和丙二醛（MDA）含量显着增加。我们的结果表明，苯可诱导FA转运和β-氧化酶，线粒体功能障碍和氧化应激的表达增加，这可能在苯诱导的血液毒性中起作用。

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