...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Environmental Research and Public Health >Co-Formulants in Glyphosate-Based Herbicides Disrupt Aromatase Activity in Human Cells below Toxic Levels
【24h】

Co-Formulants in Glyphosate-Based Herbicides Disrupt Aromatase Activity in Human Cells below Toxic Levels

机译：草甘膦基除草剂中的共制剂破坏了低于毒性水平的人类细胞中的芳香酶活性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pesticide formulations contain declared active ingredients and co-formulants presented as inert and confidential compounds. We tested the endocrine disruption of co-formulants in six glyphosate-based herbicides (GBH), the most used pesticides worldwide. All co-formulants and formulations were comparably cytotoxic well below the agricultural dilution of 1% (18–2000 times for co-formulants, 8–141 times for formulations), and not the declared active ingredient glyphosate (G) alone. The endocrine-disrupting effects of all these compounds were measured on aromatase activity, a key enzyme in the balance of sex hormones, below the toxicity threshold. Aromatase activity was decreased both by the co-formulants alone (polyethoxylated tallow amine—POEA and alkyl polyglucoside—APG) and by the formulations, from concentrations 800 times lower than the agricultural dilutions; while G exerted an effect only at 1/3 of the agricultural dilution. It was demonstrated for the first time that endocrine disruption by GBH could not only be due to the declared active ingredient but also to co-formulants. These results could explain numerous in vivo results with GBHs not seen with G alone; moreover, they challenge the relevance of the acceptable daily intake (ADI) value for GBHs exposures, currently calculated from toxicity tests of the declared active ingredient alone.
机译：农药制剂中含有已声明的活性成分和助剂，以惰性和机密化合物形式存在。我们在六种基于草甘膦的除草剂（GBH）中测试了助剂对内分泌的破坏作用，这是全球最常用的农药。相对而言，所有辅助制剂和制剂的细胞毒性都远低于1％的农业稀释度（辅助制剂为18-2000倍，制剂为8-141倍），而不是仅声明的有效成分草甘膦（G）。测量了所有这些化合物的内分泌干扰作用对芳香酶的活性，芳香酶是性激素平衡中的关键酶，低于毒性阈值。单独的共制剂（聚乙氧基牛脂胺-POEA和烷基聚葡糖苷-APG）和制剂均降低了芳香酶活性，其浓度比农用稀释剂低800倍。而G仅在农业稀释度的1/3处起作用。首次证明GBH破坏内分泌不仅是由于宣称的活性成分，还可能是由于共制剂。这些结果可以解释单独使用G时未见的大量GBH体内结果。此外，它们还挑战了GBHs暴露的每日可接受摄入量（ADI）值的相关性，目前该数据仅根据已宣布的活性成分的毒性测试得出。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号