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首页> 外文期刊>International Journal of Environmental Research and Public Health >Oxidative Stress and Genotoxicity of Long-Term Occupational Exposure to Low Levels of BTEX in Gas Station Workers
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Oxidative Stress and Genotoxicity of Long-Term Occupational Exposure to Low Levels of BTEX in Gas Station Workers

机译：长期职业接触加油站工人低水平BTEX的氧化应激和遗传毒性

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Atmospheric benzene, toluene, ethylbenzene, and xylenes (BTEX) can lead to multiple health injuries. However, what remains uncertain is the effect of long-term exposure to low levels of BTEX. Thus, we determined the BTEX levels in the air from the refueling and office areas in gas stations. Then we collected workers’ (200 refueling vs. 52 office workers) peripheral blood samples to analyze the serum total-superoxide dismutase (T-SOD), glutathione (GSH), malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG) levels. DNA damage was analyzed by the comet assay and micronucleus test in buccal epithelial cells. We found that the levels of BTEX in refueling areas were significantly higher than those in office areas (p < 0.001). The serum T-SOD and GSH of refueling workers were significantly lower than those in office workers (p < 0.001). By contrast, the serum MDA and 8-OHdG of refueling workers were significantly higher than those of office workers (p < 0.001, MDA; p = 0.025, 8-OHdG). Furthermore, tail and Olive tail moments in refueling workers were longer (p = 0.004, tail moment; p = 0.001, Olive tail moment), and the micronucleus rate was higher (p < 0.001) than those in office workers. Taken together, long-term exposure to low levels of BTEX may reduce the antioxidant ability and increase the risk of DNA damage in refueling workers of gas stations.
机译：大气中的苯，甲苯，乙苯和二甲苯（BTEX）可能导致多种健康伤害。然而，仍然不确定的是长期暴露于低水平的BTEX中的影响。因此，我们确定了加油站加油和办公室区域空气中的BTEX含量。然后，我们收集了工人（200人加油vs 52人上班族）的外周血样本，以分析血清总超氧化物歧化酶（T-SOD），谷胱甘肽（GSH），丙二醛（MDA）和8-羟基脱氧鸟苷（8-OHdG）水平。通过彗星试验和颊上皮细胞中的微核试验分析DNA损伤。我们发现，加油区的BTEX含量明显高于办公区（P <0.001）。加油工人的血清T-SOD和GSH显着低于办公室工人（p <0.001）。相比之下，加油工人的血清MDA和8-OHdG显着高于上班族（p <0.001，MDA; p = 0.025，8-OHdG）。此外，加油工人的尾部和橄榄尾部矩更长（p = 0.004，尾部矩; p = 0.001，橄榄部尾矩），并且微核率高于上班族。两者合计，长期接触低含量的BTEX可能会降低加油站加油工人的抗氧化能力并增加DNA损坏的风险。

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