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首页> 外文期刊>International Journal of Environmental Research and Public Health >Maternal Exposure to Air Pollutants and Risk of Gestational Diabetes Mellitus in Taiwan
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Maternal Exposure to Air Pollutants and Risk of Gestational Diabetes Mellitus in Taiwan

机译：台湾孕妇的空气污染物暴露和妊娠糖尿病的风险

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Mounting evidence has shown an increased risk of gestational diabetes mellitus (GDM) in association with elevated exposure to air pollution. However, limited evidence is available concerning the effect of specific air pollutant(s) on GDM incidence. We conducted this case-control study on 6717 mothers with GDM diagnosed in 2006?￠????2013 and 6717 age- and year of delivery-matched controls to further address the risk of GDM in relation to specific air pollutant. Both cases and controls were selected from a cohort of 1-million beneficiaries of Taiwan?￠????s National Health Insurance program registered in 2005. Maternal exposures to mean daily air pollutant concentration, derived from 76 fixed air quality monitoring stations within the 12-week period prior to pregnancy and during the 1st and 2nd trimesters, were assessed by the spatial analyst method (i.e., ordinary kriging) with the ArcGIS software. After controlling for potential confounders and other air pollutants, an increase in pre-pregnancy exposure of 1 inter-quartile range (IQR) for PM 2.5 and SO 2 was found to associate with a significantly elevated odds ratio (OR) of GDM at 1.10 (95% confidence interval (CI) 1.03?￠????1.18 and 1.37 (95% CI 1.30?￠????1.45), respectively. Exposures to PM 2.5 and SO 2 during the 1st and 2nd trimesters were also associated with significantly increased ORs, which were 1.09 (95% CI 1.02?￠????1.17) and 1.07 (95% CI 1.01?￠????1.14) for PM 2.5 , and 1.37 (95% CI 1.30?￠????1.45) and 1.38 (95% CI 1.31?￠????1.46) for SO 2 . It was concluded that higher pre- and post-pregnancy exposures to PM 2.5 and SO 2 for mothers were associated with a significantly but modestly elevated risk of GDM.
机译：越来越多的证据表明，与增加的空气污染暴露相关的妊娠糖尿病（GDM）风险增加。但是，关于特定的空气污染物对GDM发生率的影响的证据有限。我们对2006年至2013年确诊的6717例GDM母亲和6717年龄和分娩匹配的对照进行了病例对照研究，以进一步解决与特定空气污染物相关的GDM风险。病例和对照均选自台湾在2005年注册的100万台湾国民健康保险计划的受益人群。母亲每天的空气污染物浓度平均值来自于台湾的76个固定空气质量监测站。怀孕前12周以及妊娠第1和第2孕期，使用ArcGIS软件通过空间分析方法（即普通克里格法）进行评估。在控制了潜在的混杂因素和其他空气污染物后，发现PM 2.5和SO 2的怀孕前暴露增加了1个四分位间距（IQR）与GDM在1.10时显着提高的比值比（OR）相关（ 95％置信区间（CI）分别为1.03-1.18和1.37（95％CI 1.30-1.45），并且在第一个和第二个孕中期暴露于PM 2.5和SO 2也与显着增加OR，PM 2.5为1.09（95％CI 1.02 -1.17）和1.07（95％CI 1.01 -1.14）和1.37（95％CI 1.30 -1.14）。 SO 2的≥1.45）和1.38（95％CI1.31≥1.46），结论是母亲怀孕前和孕后暴露于PM 2.5和SO 2的比例较高，但显着但中等。 GDM的风险升高。

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