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首页> 外文期刊>International Journal of Environmental Research and Public Health >Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain
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Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain

机译：非持久性内分泌干扰物在人脑两个不同区域的分布

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Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI < 25 kg/m 2 , respectively). Nine phenols and seven parabens were measured by isotope dilution TurboFlow-LC-MS/MS. In the hypothalamus, seven suspect npEDCs (bisphenol A, triclosan, triclocarban and methyl-, ethyl-, n-propyl-, and benzyl paraben) were detected, while five npEDCs (bisphenol A, benzophenone-3, triclocarban, methyl-, and n-propyl paraben) were found in the white-matter brain tissue. We observed higher levels of methylparaben (MeP) in the hypothalamic tissue of obese subjects as compared to controls ( p = 0.008). Our findings indicate that some suspected npEDCs are able to cross the blood–brain barrier. Whether the presence of npEDCs can adversely affect brain function and to which extent the detected concentrations are physiologically relevant needs to be further investigated.
机译：非持久性内分泌干扰化学物质（npEDC）会影响体内的多个器官和系统。 npEDCs是否可以在人脑中积累尚不清楚。这项初步研究的主要目的是检查在两个不同的大脑区域（下丘脑和白色物质组织）中环境酚和对羟基苯甲酸酯的存在。另外，研究了这些npEDCs浓度与肥胖之间的潜在关联。死后大脑材料来自24名个体，由12名肥胖者和12名体重正常的受试者组成（分别定义为体重指数（BMI）> 30和BMI <25 kg / m 2）。通过同位素稀释TurboFlow-LC-MS / MS测定了九种酚和七种对羟基苯甲酸酯。在下丘脑中，检测到七个可疑的npEDC（双酚A，三氯生，三氯卡班和对羟基苯甲酸甲酯，乙基，正丙基和对羟基苯甲酸苄酯），而五个npEDC（双酚A，二苯甲酮3，三氯卡班，甲基和在白色物质的脑组织中发现了对羟基苯甲酸正丙酯。与对照组相比，我们观察到肥胖受试者下丘脑组织中对羟基苯甲酸甲酯（MeP）的含量较高（p = 0.008）。我们的发现表明，一些可疑的npEDC能够穿过血脑屏障。 npEDCs的存在是否会对脑功能产生不利影响，以及检测到的浓度在多大程度上与生理相关，需要进一步研究。

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